Efficacy and safety of herbal medicine Yijin-tang on polycystic ovary syndrome: A single-arm pilot study

Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery

“… Improvement of oligomenorrhea. ↓Number of ovarian follicles [ 94 ] SHBG, sex hormone binding globulin; SOD, superoxide dismutase; TC, total cholesterol; TG, triglycerides; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HOMA-IR, homeostatic model assessment of insulin resistance; QUICKI, quantitative insulin-sensitivity check index; IL-6, interleukin 6; TNF-α, tumor necrosis factor-α; hs-CRP, high-sensitivity C-reactive protein; VLDL-cholesterol, very-low-density lipoprotein-cholesterol; DHEA-S, dehydroepiandrosterone sulfate; CAT, catalase; GPx, glutathione peroxidase; MDA, malondialdehyde; FBS, Fast blood sugar; HDL-C, low-density lipoprotein cholesterol; LDL-C, low-density lipoprotein-cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ISI, insulin-sensitive index; ↑, up-regulation; ↓, down-regulation.

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“…Yijin-tang (YJT) is a traditional medicine prescribed for the prevention and treatment of diverse diseases, which is composed of Pinellia ternata Breitenbach, Citrus unshiu Markovich, Poria cocos Wolf, Glycyrrhiza uralensis Fisch, and Zingiber officinale Roscoe [ 94 ]. 15 patients with oligomenorrhea due to PCOS were included in the study.…”

“…Five studies inhibit TC and six substances that inhibit T [ 73 , 76 , 77 , 83 , [86] , [87] , [88] , [89] , 92 ]. Studies using 12 substances improved the menstrual cycle's regularity and oligomenorrhea [ 71 , 74 , 75 , 79 , 82 , 85 , 87 , [89] , [90] , [91] , 93 , 94 ]. In addition, 8 studies controlled the effect of hormones, and 3 studies increased the rate of pregnancy [ 71 , 72 , 77 , 81 , 83 , 84 , 89 , 92 , 93 ].…”

A Case Report of Yin-deficiency Related Symptoms Improved with Korean Medicine Treatment: Focusing on the Yijin Samul-tang Gagam (二陳四物湯加減)

“…호르몬 관련 질환에 효과가 있다는 연구가 존재한다 1,2) . 이진탕 은 한의 병리 병인 중 '담음(痰飮)'을 치료하는 대표적인 처방으 로 다낭성난소증후군, 고지혈증, 죽상동맥경화증에 치료기전 이 연구되어 있다 [3][4][5]…”