Efficacy and safety of herbal medicines in treating gastric ulcer: A review

Abstract

Gastric ulcer is a common disorder of the digestive system. Current therapeutic regimens largely rely on Western medicine. However, numerous studies have demonstrated that herbal medicines can effectively treat gastric ulcer in humans and various animal models via divergent mechanisms. This review updates the efficacy and safety of herbal medicines in treating gastric ulcer, and the mechanisms of their action in humans and animal models. Studies have demonstrated that the efficacy of herbal medicines is comparable or superior to that of drugs such as omeprazole or cimetidine in humans and animal models, and herbal medicines display fewer adverse effects. The mechanisms by which herbal medicines benefit gastric ulcer include stimulation of mucous cell proliferation, anti-oxidation, and inhibition of gastric acid secretion and H(+)/K(+)-ATPase activity. Some herbal medicines also exhibit antimicrobial properties. Utilization of herbal medicines could be a valuable alternative to treat gastric ulcer in humans effectively, with few adverse effects.

Laetiporus sulphureus (Bull.: Fr.) Murr. as Food as Medicine

“…Thus, a valuable alternative to treat the disease in humans is utilization of herbal formulations that are effective in healing experimentally induced gastric ulcer. 60 Wang et al (2015) investigated on antiinflammatory and tumor inhibiting effects of eburicoic acid, the main bioactive component in L. sulphureus, on gastric ulcers. The results showed that oral administration of eburicoic acid protected gastric mucosa from gastric lesions morphologically and especially attenuated H+/K+-ATPase activity.…”

Substantiation of the Medicine With Dry Extract of Hop Cones in the Form of Hard Gelatine Capsules for Treatment of Gastrointestinal Diseases Development Expediency

“…The neurotropic effect of galenic preparations from cones of hop is associated with the presence of lupulin, which has a calming effect on the central nervous system. Anti-inf lammatory, analgesic, bactericidal and antiallergic properties of herbal preparations of the plant determine their therapeutic effectiveness in diseases of the skin and mucous membranes, accompanied by inflammatory lesions, allergic manifestations, itching and other symptoms [4,5].…”

“…Therefore, we consider it advisable to conduct research on the development of the composition and technology of a solid dosage form for the treatment of pathologies caused by inflammation in the internal organs, for example gastritis or gastric ulcer [4,6].…”

A New Participant in the Pathogenesis of Alcoholic Gastritis: Pyroptosis

“…Increased levels of inflammation with the release of large amounts of cytokines are the main features of gastritis [50][51][52][53]. It has become clear that bacteria have caused gastritis in the overwhelming majority of the cases recorded since 1982 [54].…”