Efficacy and safety of hexaminolevulinate photodynamic therapy in patients with low‐grade cervical intraepithelial neoplasia

Abstract

HAL PDT shows a favorable efficacy and safety profile and represents a promising alternative to observation and surgical procedures in patients with CIN 1.

Efficacy and safety of photodynamic therapy for cervical intraepithelial neoplasia and human papilloma virus infection

“…1). Moreover, the risks of bias for randomization and allocation in three RCTS [24–26] are unclear. The 2015 study by Hillemanns et al [25] represents the largest study with a weight of 48.1% in the meta-analysis of CRR in CIN patients.…”

“…Fu et al [26] represents the largest study with a weight of 48.6% in the meta-analysis of CRR in cervical HPV. The 2014 study by Hillemanns et al [24] is the largest study with a weight of 86.8% in the meta-analysis of AER in patients receiving PDT. Moreover, the total number of events with each outcome was less than 300.…”

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

“…Due to the high rate of spontaneous HPV clearance, no significant difference was seen in the eradication of high risk HPV between the PDT and the control groups. Nevertheless, HAL-PDT showed high clearance rates and a favourable safety profile compared to surgery [ 245 ]. A follow-up study showed no significant effect of HAL-PDT compared to placebo groups for CIN1/2, but a significantly improved response was seen compared to placebo in CIN2 patients, which sustained towards the 6-month follow up.…”

Inactivation of Malaria Parasites in Blood: PDT vs Inhibition of Hemozoin Formation

“…In gastroenterology, PDT demonstrated its effectiveness for the treatment of superficial cancers of the esophagus in patients ineligible for further treatment, with a postradiation recurrence, severe dysplasia in Barrett, and unresectable cholangiocarcinoma [59]. In gynecology, the interest of PDT has been shown in the treatment of cervical dysplasia of low-and high-grade cervical lesions [60]. Our team developed folic acid-targeted photosensitizers that could be very efficient to treat peritoneal carcinosis, and a preclinical evaluation is under progress [61,62].…”