Efficacy and safety of hydrolyzed rice-protein formulas for the treatment of cow's milk protein allergy

Bocquet, A.; Dupont, Christophe; Chouraqui, J.-P.; Darmaun, Dominique; Feillet, François; Frelut, M.-L.; Girardet, Jean-Philippe; Hankard, R.; Lapillonne, Alexandre; Rozé, J. C.; Simeoni, Umberto; Turck, Dominique; Briend, André

doi:10.1016/j.arcped.2019.03.001

Cited by 60 publications

(65 citation statements)

References 37 publications

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“…The energy content and lipid composition of HRPFs is comparable to that of standard infant or follow-on formulas [3] (Table 3). The nutritional value of a protein depends on its digestibility coefficient:…”

Section: Energy Protein Lipid and Carbohydrate Content Of Hrpfmentioning

confidence: 73%

“…Literature data indicate that 5 different HRPF brands have been tested in Italy (1), the United States (1), Spain (1), and France (2) [3].…”

Section: Hrpf Market Availabilitymentioning

confidence: 99%

“…Rice grain has low allergenicity, and rice protein allergy is uncommon in publications from Western countries [3,81]. Rice triggers adverse reactions in less than 1% of allergic children and it is considered as the least allergenic cereal [82].…”

Section: Allergenic Tolerance Of Rice and Of Hrpfsmentioning

confidence: 99%

“…Growth in the first months of life to two years of age in infants with CMPA fed a HRPF (Table 6) was evaluated in five studies [3]. A significant growth retardation existed in most studies [68,81,87].…”

Section: Growth Evolution and Protein Nutritional Statusmentioning

confidence: 99%

“…In the last two decades, formulas based on hydrolyzed rice protein (HRP) have been developed and they seem to be a valid alternative to cow's milk protein (CMP) formulas, both as a vegetal alternative for families interested in plant-based feeding and for children with CMPA [3]. HRPFs may be considered as a part of a trend towards plant-based sources of protein, which may be beneficial on human health, mortality [4] and may have an impact on the environment, hence its potential growing use in infants and children.…”

Section: Introductionmentioning

confidence: 99%

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Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow’s Milk Allergy

et al. 2020

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Formulas adapted to infant feeding, although most of the time made from cow’s milk proteins, can be made from hydrolyzed rice protein but they must be classified as “formulas for specific medical needs”, according to European regulations. The nutritional quality of rice proteins is thus suitable to be used in infant formulas giving that it is supplemented by certain amino acids which can be lacking. Besides, hydrolysis is required to facilitate their water solubility and digestibility. Owing to a low allergenicity of rice and to the absence of the cross-allergy between milk proteins and rice proteins, these formulas are adapted to the diet of children with cow’s milk protein allergy (CMPA), which explains their growing use in some countries. However, CMPA, an expanding disorder, has consequences for growth, bone mineralization, and often has an association with allergy to other foods, including cow’s milk extensive hydrolysate, so that a surveillance of the adaption of hydrolyzed rice protein formulas (HRPF) to CMPA, the absence of unexpected side effects, and the appropriate response to its various health hazards seems mandatory. This paper analyses the health problem deriving from CMPA, the industrial development of hydrolyzed rice protein formulas, and the limited number of clinical studies, which confirms, at the moment, a good allergic tolerance and safety. The goal is to better advise heath care professionals on their use of HRPFs during CMPA.

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Section: Energy Protein Lipid and Carbohydrate Content Of Hrpfmentioning

confidence: 73%

“…Literature data indicate that 5 different HRPF brands have been tested in Italy (1), the United States (1), Spain (1), and France (2) [3].…”

Section: Hrpf Market Availabilitymentioning

confidence: 99%

Section: Allergenic Tolerance Of Rice and Of Hrpfsmentioning

confidence: 99%

Section: Growth Evolution and Protein Nutritional Statusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow’s Milk Allergy

et al. 2020

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Infant Formulae

MALTERRE,

ALONSO‐MIRAVALLES,

O'MAHONY

2024

Milk and Dairy Products

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Growth pattern of paediatric patients affected by cow milk protein allergy fed with rice hydrolyzed formula

Nocerino,

Coppola,

Carucci

et al. 2024

J. pediatr. gastroenterol. nutr.

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ObjectivesFormulas made from hydrolyzed rice proteins (HRPF) are well‐tolerated plant‐based alternatives to cow's milk protein (CMP)‐based formulas for the dietary management of paediatric patients with CMP allergy (CMPA). Growth in patients with CMPA fed with HRPF has been evaluated in several studies with conflicting results. The aim was to evaluate the growth pattern of children with CMPA over a 12‐month follow‐up period.MethodsProspective cohort study evaluating growth patterns in challenge proven CMPA paediatric patients receiving HRPF for 12 months. Outcomes were anthropometry (body weight, body length, head circumference), adherence to the study formula and occurrence of adverse events (AEs).ResultsSixty‐six children were included and completed the 12‐month study. At baseline, all CMPA patients were weaned. For the entire CMPA pediatric patients' cohort, from baseline to the end of the study period, the growth pattern resulted within the normal range of WHO growth references. The formula was well tolerated. Adherence was optimal and no AEs related to HRPF use were reported.ConclusionsHRPF is well tolerated and can help support healthy growth and development in infants and young children with CMPA. These type of formula can be given with complementary foods in the dietary management of CMPA.

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Efficacy and safety of hydrolyzed rice-protein formulas for the treatment of cow's milk protein allergy

Cited by 60 publications

References 37 publications

Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow’s Milk Allergy

Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow’s Milk Allergy

Infant Formulae

Growth pattern of paediatric patients affected by cow milk protein allergy fed with rice hydrolyzed formula

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