Efficacy and Safety ofCissus quadrangularisL. in Clinical Use: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Abstract

Cissus quadrangularis L. (Cissus) is a medicinal plant commonly used for centuries for various conditions, but lacks critical appraisal of its clinical effects. This study aimed to determine the efficacy and safety of Cissus in all conditions. Publications from 12 electronic databases were searched from inception through November 2016. A total of nine studies with 1108 patients were included. Each outcome was pooled using a random effects model. Effects of Cissus on hemorrhoid symptoms were not different from any comparators but had significant effects on bone pain. Effects of Cissus combination products on body weight reduction, low-density lipoprotein, triglyceride, total cholesterol, and fasting blood sugar were superior to placebo, with weighted mean difference of -5.19 kg (-8.82, -1.55), -14.43 mg/dl (-20.06, -8.80), -37.50 mg/dl (-48.71, -26.29), -50.50 mg/dl (-70.97, -30.04), and -10.39 mg/dl (-14.60, -6.18), respectively. No serious adverse effects were reported. Quality of evidence based on Grades of Recommendations Assessment Development and Evaluation (GRADE) indicated low (bone fractures) to high quality (hemorrhoids, body weight reduction).In conclusion, Cissus had benefit for bone fractures, but not for hemorrhoids. For obesity/overweight, only combination products are pooled and show benefit. However, high-quality studies remain needed. Copyright © 2017 John Wiley & Sons, Ltd.

Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

“…However, these effects were observed in RCTs of only 8 to 10 weeks’ duration, and all of the two to three studies conducted on each of these herbal medicines were by the same research groups, which introduces a high risk of selective reporting and confirmation bias, therefore, more evidence is needed before a definitive decision on their effect on weight loss can be reached. This conclusion is consistent with a 2017 systematic review of C. quadrangularis and a 2013 systematic review of I. gabonensis . In contrast, our review revealed inconsistent results among the few studies on I. paraguariensis and G. glabra , perhaps due to the varied combination preparations studied.…”

Osteoprotective Medicinal Plants - Part 1 (A Human Clinical Evidence-Based Review)

“…A systematic review on the randomized controlled trials available in the present concluded that no serious adverse effects were reported with the use of Cissus quadrangularis (Sawangjit et al, 2017).…”

Cissus quadrangularis extract (CQR-300) inhibits lipid accumulation by downregulating adipogenesis and lipogenesis in 3T3-L1 cells

“…It has been utilized in Ayurveda as an alternative medicine to treat bone fracture, digestive, eye, ear diseases, and asthma for more than a century [ 9 , 11 ]. Fresh stems and roots of C. quadrangularis have been used as food and management for various ailments [ 11 , 13 ]. Several studies have shown that C. quadrangularis has compounds such as friedelin, α-amyrone, resveratrol, piceatannol, quercetin, and pallidol with various metabolic and pharmacological properties [ 14 , 15 , 16 , 17 , 18 , 19 ].…”