Efficacy and Safety of
            <i>EGFR</i>
            Inhibitors and Radiotherapy in Locally Advanced Non-Small-Cell Lung Cancer: a Meta-Analysis

Li, Xue; Wang, Fang; Jia, Huijun; Lian, Zhen; Ren, Kai; Wang, Ping; Zhao, Lujun

doi:10.2217/fon-2022-0491

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…or exon 21 arginine substitution leucine (L858R) mutation. EGFR inhibitors such as Gefitinib, Erlotinib, Afatinib, or Osimertinib play an important role in the treatment of NSCLC patients ( 58 ). However, some studies have shown that the proportion of NSCLC patients carrying EGFR mutations is about 30-40%, and there are still a large number of patients who cannot benefit directly from targeted therapy ( 59 ).…”

Section: Discussionmentioning

confidence: 99%

A novel prognostic model related to oxidative stress for treatment prediction in lung adenocarcinoma

Peng

Luan

et al. 2023

Front. Oncol.

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BackgroundThe prognostic model based on oxidative stress for lung adenocarcinoma (LUAD) remains unclear.MethodsThe information of LUAD patients were acquired from TCGA dataset. We also collected two external datasets from GEO for verification. Oxidative stress-related genes (ORGs) were extracted from Genecards. We performed machine learning algorithms, including Univariate Cox regression, Random Survival Forest, and Least Absolute Shrinkage and Selection Operator (Lasso) analyses on the ORGs to build the OS-score and OS-signature. We drew the Kaplan-Meier and time-dependent receiver operating characteristic curve (ROC) to evaluate the efficacy of the OS-signature in predicting the prognosis of LUAD. We used GISTIC 2.0 and maftool algorithms to explore Genomic mutation of OS-signature. To analyze characteristic of tumor infiltrating immune cells, ESTIMATE, TIMER2.0, MCPcounter and ssGSEA algorithms were applied, thus evaluating the immunotherapeutic strategies. Chemotherapeutics sensitivity analysis was based on pRRophetic package. Finally, PCR assays was also used to detect the expression values of related genes in the OS-signature in cell lines.ResultsTen ORGs with prognostic value and the OS-signature containing three prognostic ORGs were identified. The significantly better prognosis of LUAD patients was observed in LUAD patients. The efficiency and accuracy of OS-signature in predicting prognosis for LUAD patients was confirmed by survival ROC curves and two external validation data sets. It was clearly observed that patients with high OS-scores had lower immunomodulators levels (with a few exceptions), stromal score, immune score, ESTIMATE score and infiltrating immune cell populations. On the contrary, patients with higher OS-scores were more likely to have higher tumor purity. PCR assays showed that, MRPL44 and CYCS were significantly higher expressed in LUAD cell lines, while CAT was significantly lower expressed.ConclusionThe novel oxidative stress-related model we identified could be used for prognosis and treatment prediction in lung adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

A novel prognostic model related to oxidative stress for treatment prediction in lung adenocarcinoma

Peng

Luan

et al. 2023

Front. Oncol.

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Cancer therapy-related interstitial lung disease

Zhou,

Deng,

Yang

et al. 2024

Chinese Medical Journal

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With the increasing utilization of cancer therapy, the incidence of lung injury associated with these treatments continues to rise. The recognition of pulmonary toxicity related to cancer therapy has become increasingly critical, for which interstitial lung disease (ILD) is a common cause of mortality. Cancer therapy-related ILD (CT-ILD) can result from a variety of treatments including chemotherapy, targeted therapy, immune checkpoint inhibitors, antibody–drug conjugates, and radiotherapy. CT-ILD may progress rapidly and even be life-threatening; therefore, prompt diagnosis and timely treatment are crucial for effective management. This review aims to provide valuable information on the risk factors associated with CT-ILD; elucidate its underlying mechanisms; discuss its clinical features, imaging, and histological manifestations; and emphasize the clinical-related views of its diagnosis. In addition, this review provides an overview of grading, typing, and staging treatment strategies used for the management of CT-ILD.

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Efficacy and Safety of EGFR Inhibitors and Radiotherapy in Locally Advanced Non-Small-Cell Lung Cancer: a Meta-Analysis

Cited by 2 publications

References 48 publications

A novel prognostic model related to oxidative stress for treatment prediction in lung adenocarcinoma

A novel prognostic model related to oxidative stress for treatment prediction in lung adenocarcinoma

Cancer therapy-related interstitial lung disease

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