Efficacy and Safety of Ibuprofen for Hemophilic Arthropathy

Hasiba, Ute

doi:10.1001/archinte.1980.00330230029010

Cited by 19 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Abnormal bleeding times have been reported in a variety of disorders not thought of as primarily platelet-related (the degree to which these disorders may prolong the bleeding time on the basis of altered platelet count, mass, or efficacy is not established). The list of diseases includes amyloidosis 139 ; Barrier's syndrome 140 ; glycogen storage disease type I 141 ; congenital heart disease 73 97 142 143 ; diseases affecting tissue integrity, such as scoliosis 35 144 145 and collagen defects 146 (including osteogenesis imperfecta 147 148 and Ehlers-Danlos syndrome 149 ); neurofibromatosis, 3 dysfibrinogenemia 150 ; deficiencies of fibrinogen 151 152 153 or coagulation factors V, 154 155 156 157 VII, 158 159 160 161 VIII, 5 22 98 157 162 163 164 165 166 167 168 169 170 171 IX, 98 157 166 168 169 172 173 174 175 176 177 178 X, 179 180 181 XI, 166 175 179 182 183 184 185 or XII 157 ; the presence of factor VIII inhibitors…”

Section: Discussionmentioning

confidence: 99%

A Critical Reappraisal of the Bleeding Time

Rodgers,

Levin

2023

Semin Thromb Hemost

View full text Add to dashboard Cite

Seminars in Thrombosis and Hemostasis (STH) celebrates 50 years of publishing in 2024. To celebrate this landmark event, STH is republishing some archival material. This manuscript represents the second most highly cited paper ever published in STH. The manuscript published without an abstract, and essentially represented a State of the Art Review on the bleeding time, a relatively invasive procedure that required an incision on the skin or earlobe of a patient, and timing how long it took for the incision to stop bleeding. The bleeding time test was first described in 1901 by the French physician Milian, who presented three studies of bleeding from stab wounds made in the fingertips of healthy and diseased subjects. In 1910, Duke observed the duration of bleeding from small incisions of the ear lobe, and pointed out that the duration of bleeding was increased in instances of reduced platelet counts. The test was subsequently repeatedly modified, and numerous variants of the test, including semiautomated methods, were described by several workers. The most frequently utilised test reflected one described by Ivy and coworkers, who shifted the location of the incision to the volar aspect of the forearm and applied a blood pressure cuff to the arm to maintain a standard venous pressure. The bleeding time has been proposed for use as a diagnostic test for platelet-related bleeding disorders, a measure of efficacy in various forms of therapy, and as a prognosticator of abnormal bleeding. The authors to the current review reevaluated the bleeding time literature using methods to assess the performance of the test in 1990, locating 862 printed documents that discussed the bleeding time, the majority in peer-reviewed professional journals. As this is a republication of archival material, transformed into a modern format, we apologise in advance for any errors introduced during this transformation.

show abstract

Section: Discussionmentioning

confidence: 99%

A Critical Reappraisal of the Bleeding Time

Rodgers,

Levin

2023

Semin Thromb Hemost

View full text Add to dashboard Cite

show abstract

“…The study was therefore conducted using IBU in comparison with PLAC. It has previously been shown that IBU has little effect on platelet function [McIntyre et al, 1978;Hasiba et al, 1980] and the drug has been used empirically in haemophiliacs. One controlled study showed IBU to be more effective than PLAC in reducing morning stiffness and al lowed reduction of other analgesic medica tion in some patients [Inwood et al, 1983], Our study has confirmed the superiority of IBU over PLAC and only 1 patient had to discontinue the active drug on account of dyspepsia.…”

Section: Discussionmentioning

confidence: 99%

“…Studies on IBU were not carried out, as previous studies [McIntyre ct ah, 1978;Hasiba et al, 1980] showed the drug to have no adverse effects on platelet function in vitro. Initially, assessment of the drugs was carried out in normal sub jects and thereafter was repeated in the haemophilic patients.…”

Section: Laboratory Studiesmentioning

confidence: 99%

Non-Steroidal Anti-Inflammatory Drugs in Haemophilic Arthritis

Steven

Small

Pinkerton

et al. 1985

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

Non-steroidal anti-inflammatory drugs are theoretically contra-indicated in the haemophilias but might be useful for those patients with chronic arthritic pain, as long-term strong analgesics are also undesirable. We carried out studies of platelet function and coagulation in 8 normal controls and 7 haemophiliacs while they were taking sequentially benoxaprofen and salsalate. No significant alterations in platelet function, bleeding time or coagulation occurred with either drug. In a subsequent double-blind controlled clinical trial using ibuprofen and placebo 8 of 9 patients had a significant reduction in pain score whilst using ibuprofen without significant change in the frequency of bleeds or the amount of concentrate used. Laboratory measures of coagulation also failed to reveal any adverse effect of the active drug. Non-steroidal anti-inflammatory drugs may be beneficial and may be used with caution in haemophilia.

show abstract

“…Bila terpaksa dapat digunakan penghilang rasa nyeri seperti propoksifen, asetaminofen, ibuprofen, meperidin, kodein, petidin atau metadon sebagai alternatif. 5,22,25 Obat anti inflamasi Pada hemartrosis akut dapat digunakan kortikosteroid dengan dosis (prednison) 1-2 mg per kilogram berat badan selama 3-5 hari dan tidak melebihi 14 hari untuk sinovitis kronis. 22 Pada degenerasi sendi yang telah menetap dan adanya sinovitis persisten, injeksi steroid intra-artikular dapat menolong membebaskan rasa nyeri, tetapi pemakaian-nya harus dilindungi terapi pengganti dengan faktor yang sesuai.…”

Section: Analgesikunclassified

Hemartrosis pada Hemofilia

Gatot¹,

Handryastuti²

2016

View full text Add to dashboard Cite

show abstract

Efficacy and Safety of Ibuprofen for Hemophilic Arthropathy

Cited by 19 publications

References 5 publications

A Critical Reappraisal of the Bleeding Time

A Critical Reappraisal of the Bleeding Time

Non-Steroidal Anti-Inflammatory Drugs in Haemophilic Arthritis

Hemartrosis pada Hemofilia

Contact Info

Product

Resources

About