“…Infections such as empyema occur in approximately 5% of cases, and mortality related to such infections is less than 1%, 100 , 101 including patients undergoing oncological treatment in whom the IPC can be placed at any time during oncological treatment without altering the efficacy and safety of IPC. 102 Unless drainage is inadequate, most catheter-related infections can be treated by leaving the IPC in place, supplemented with systemic antibiotic therapy and intrapleural enzyme therapy through the catheter. 103 Another complication is symptomatic loculation, which is treated with intrapleural enzyme therapy.…”