Efficacy and Safety of Inhaled Zanamivir in the Prevention of Influenza in Community-Dwelling, High-Risk Adult and Adolescent Subjects: A 28-day, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Oseltamivir, zanamivir and amantadine in the prevention of influenza: A systematic review

“…For the use of zanamivir in seasonal prophylaxis in at-risk adults and adolescents, comparable effects were observed, with relative risks of 0.17 (95% CI 0.02e1.41) and 0.17 (95% CI 0.05e0.58) of developing SLCI in vaccinated and unvaccinated subjects respectively. 73 Of the cases of SLCI that were observed in a trial 66 of zanamivir in outbreak control all occurred in unvaccinated subjects.…”

Oseltamivir and inhaled zanamivir as influenza prophylaxis in Thai health workers: a randomized, double-blind, placebo-controlled safety trial over 16 weeks

“…The neuraminidase inhibitors oseltamivir and zanamivir are generally effective for preventing laboratory-confirmed influenza when used for limited time periods as primary 8–11 or post-exposure 12–14 prophylaxis in healthy adults, 8 individuals with comorbidities, 9 healthy soldiers 12 and households. 13,14 Systematic reviews are in accordance with the findings of individual studies.…”

Prodrug, Laninamivir Octanoate, a Long-Acting NeuraminidaseInhibitor, Using an Easy-to-Use Inhaler in Healthy Volunteers

“…As an inhaled neuraminidase inhibitor, zanamivir was efficacious in twice daily treatment for 5 days [2], and was also efficacious for the prevention of influenza with self-administration once daily for up to 10 days in families [3]. In addition, zanamivir was successful in preventing infection with the predominant strains circulating in the 2000-2001 influenza season in high-risk community-dwelling subjects for up to 28 days [11]. It is reported that LO has substantial efficacy as both a therapeutic and a prophylactic agent against H5N1 influenza viruses in mice.…”