Efficacy and safety of injection with poly-L-lactic acid compared with hyaluronic acid for correction of nasolabial fold: a randomized, evaluator-blinded, comparative study

Hyun, Moo Yeol; Lee, Youngsub; No, Yeon A; Yoo, Kwang Ho; Kim, M. N.; Hong, Chang Kwun; Chang, Sung Eun; Won, Chong Hyun; Kim, B. J.

doi:10.1111/ced.12499

Cited by 27 publications

(23 citation statements)

References 22 publications

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“…The sample size was calculated with a power of 80%. 11 The differences between pre-and posttreatment were analyzed by a paired t-test, and the comparisons between the groups were performed using independent 2-sample t-tests with a false discovery rate method. To determine age effect, independent t-tests with the false discovery rate method and chi-square tests were used.…”

Section: Discussionmentioning

confidence: 99%

Quantitative and perceived visual changes of the nasolabial fold following orthodontic retraction of lip protrusion

Baek

Hwang

Choi

et al. 2018

The Angle Orthodontist

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Section: Discussionmentioning

confidence: 99%

Quantitative and perceived visual changes of the nasolabial fold following orthodontic retraction of lip protrusion

Baek

Hwang

Choi

et al. 2018

The Angle Orthodontist

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“…In this study, the efficacy and safety of PDLLA microspheres injections for the correction of nasolabial folds were compared with those of HA. PDLLA microspheres were not inferior to HA [22] , and 30 subjects completed the 24-month long-term safety evaluation follow up, which showed that PDLLA microspheres are safe and effective for use as fillers for nasolabial fold correction [23] . Complications such as granuloma formation [24][25][26][27] and accidental vascular occlusion [26][27][28] could occur, similar to other subdermal fillers, and need to be investigated further.…”

Section: Discussionmentioning

confidence: 90%

Efficacy and safety of poly-D,L-lactic acid microspheres as subdermal fillers in animals

Lin¹,

Lin²,

Yang³

et al. 2019

PAR

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Aim: This animal study aims to examine the efficacy and safety of poly-D,L-lactic acid (PDLLA) microspheres as subdermal fillers. Methods: Thirty 2-week-old male Sprague Dawley rats were used as test animals, and 0.5 mL filler solutions were injected into the subdermal tissues on their backs. Groups of five rats were randomly selected and sacrificed for examination on the 2nd, 4th, 8th, 12th, 16th, and 20th weeks after injection. Clinical and histological examinations were performed via the hematoxyline-eosin and immunohistochemical (IHC) staining of injected sites after collecting the injected masses. The body weights of the rats were measured, and the presence of filler substance in other organs was determined. Results: Injected volumes were stable from the 2nd to the 20th week after injection, and no abnormalities were observed around the injection sites. The injected substance did not migrate to the surrounding tissues. In IHC staining experiments, myofibroblasts were observed from the 2nd week, and collagen was detected from the 4th week. Myofibroblast was observed in the spaces between and inside the microspheres in the 8th week after injection, whereas type I collagen was found between and inside the microspheres at 8th and 12th weeks, respectively. Conclusion: The animal experiments confirm the efficacy and safety of injectable PDLLA as a subdermal filler.

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“…Of particular importance to us is the fact that the use of a needle is not capable of depositing RHA homogeneously in the skin of the face, and more specifically because we humans loose collagen all over the surface of our skin but still injectors treat specific areas such as the nasolabial folds, the lips, or the frontal aspect of the cheeks. [ 23 24 ]…”

Section: Discussionmentioning

confidence: 99%

“…We advocate that depositing RHA in small amounts through large surfaces of the skin is also better to induce fibroblasts to synthesize new collagen. It is very clear that RHA can enhance the manufacture of new collagen and it does not seem worse than other products;[ 24 27 28 ] One recent study detected that RHA could improve 1.54 points in the Wrinkle Severity Rating Scale in comparison with 2.09 points improved by PLLA. Second, we believe that all HA are composed of particles some of which are “glued” with noncross-linked HA.…”

Section: Discussionmentioning

confidence: 99%

The liquid lift: Looking natural without lumps

Felipe¹,

Redondo²

2015

J Cutan Aesthet Surg

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Context:Hyaluronic acid (HA) is the most common filler used to rejuvenate. Today, a three-dimensional approach prevails over previous techniques in which this material was used in specific areas of the face such as the nasolabial fold, the marionette line, and the eye trough giving a strange appearance that does not look natural. Even with a volumizing purpose, the injection of HA can sometimes produce clinically detectable nodules or lumps where the filler is deposited.Aims:To develop a new technique of injecting HA that can provide more natural results and avoid the lumpiness and nodular appearance that sometimes occurs with the injection of HA. To detect whether mixing HA with diluted anesthetic agent modifies its behavior.Settings and Design:Prospective, case control, single-center study on a private clinic setting.Materials and Methods:Eighty six patients were enrolled in this study. All of them had a previous treatment with nondiluted HA using a needle at least a year before. Patients were injected with 8 mL of reticulated HA (RHA) mixed with 6 mL of saline and 2 mL of anesthetic agent. The mixture was administered through a cannula inserted in the face, one at mid-cheek and another at frontal-temporal point of entry. Owing to the lifting effect of this mixture we called this procedure liquid lift (LL). Patients were evaluated 1 month, 6 months, and a year later and asked to compare the LL with previous experiences in terms of natural look, pain, and appearance of nodules.Statistical Analysis Used:Student's t-test.Results:One month after the treatment, 83 out of 86 patients (96.5%) thought LL produced a more natural look than the previous treatment with the needle. Sixty two (72%) considered LL less painful than the previous treatment and only eight (9.3%) could detect lumps or nodules 1 month after LL was performed compared with 46 (53.5%) that described this problem with previous needle injections. The incidence of bruising was also clearly lower (7% with LL vs 17.4% with traditional needle).Conclusions:Injection of diluted HA with saline and anesthetic agents through a cannula all over the face or LL can provide more natural results and less lumps or nodules, and is less painful than traditional treatments involving needle injection of nondiluted HA.

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Efficacy and safety of injection with poly-L-lactic acid compared with hyaluronic acid for correction of nasolabial fold: a randomized, evaluator-blinded, comparative study

Abstract: PLA provides noninferior efficacy compared with HA 6 months after being used to treat moderate to severe nasolabial folds.

Cited by 27 publications

References 22 publications

Quantitative and perceived visual changes of the nasolabial fold following orthodontic retraction of lip protrusion

Quantitative and perceived visual changes of the nasolabial fold following orthodontic retraction of lip protrusion

Efficacy and safety of poly-D,L-lactic acid microspheres as subdermal fillers in animals

The liquid lift: Looking natural without lumps

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