Abstract:BACKGROUND: Chronic granulomatous disease (CGD) is a primary immunodeficiency with increased susceptibility to several bacteria, fungi, and mycobacteria, caused by defective or null superoxide production by the NADPH oxidase enzymatic complex. Accepted treatment consists mainly of antimicrobial prophylaxis. The role of human recombinant subcutaneous interferon gamma (IFNγ) is less clear, as available clinical evidence on its safety and efficacy is scarce and conflicting.
OBJECTIVE: We aimed to assess the effic… Show more
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