Efficacy and Safety of Intracavernosal Injection of Autologous Platelet Rich Plasma for Treatment of Erectile Dysfunction

Raaia, Mohamed F.; Elkhiat, Yasser; Guindi, A. M. el; Gebaly, Mostafa A. El; Abdelhafez, Ahmed M.

doi:10.37506/v10/i12/2019/ijphrd/192414

Cited by 2 publications

(2 citation statements)

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“…Ultimately, we included 10 literature references in this study ( 15 - 24 ) ( Figure 1 ). Among them, 7 articles were prospective non-randomized studies (6 single-arm studies and 1 double-arm study) ( 15 , 18 , 19 , 21 - 24 ), and 3 articles were RCTs ( 16 , 17 , 20 ). A total of 559 ED patients were analyzed.…”

Section: Resultsmentioning

confidence: 99%

“…After evaluating with the MINORS scale, among the included 7 non-randomized studies, the scores of 6 single-arm studies ranged from 13 to 15 ( 15 , 18 , 19 , 21 , 22 , 24 ), and the score of 1 two-arm study was 22 ( 23 ), which was acceptable for our meta-analysis ( Appendix 3 , Table S3 ). Additionally, the 3 included RCT studies were assessed using the modified Jadad scale ( 16 , 17 , 20 ), with scores ranging from 6 to 7, indicating that they were all high-quality studies ( Appendix 3 , Table S4 ).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and safety of platelet-rich plasma (PRP) in erectile dysfunction (ED): a systematic review and meta-analysis

Huang,

Qin,

Wen

et al. 2024

Transl Androl Urol

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of platelet-rich plasma (PRP) in erectile dysfunction (ED): a systematic review and meta-analysis

Huang,

Qin,

Wen

et al. 2024

Transl Androl Urol

View full text Add to dashboard Cite

Platelet-rich plasma for the treatment of erectile dysfunction: a systematic review of preclinical and clinical studies

Poulios,

Mykoniatis,

Pyrgidis

et al. 2023

Sexual Medicine Reviews

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Introduction There has been tremendous growth in regenerative medicine during the last decade. For erectile dysfunction (ED), after the inclusion of low-intensity shockwave therapy as a treatment modality for ED management by the European Association of Urology sexual health guidelines, intracavernosal injection of platelet-rich plasma (PRP) has gained popularity between urologists and patients as a novel ED therapeutic modality with initial promising results. However, limited clinical data exist regarding efficacy and safety in patients with ED. Furthermore, despite numerous preclinical studies in other tissues and organs, the mechanism of action for restoring erectile function remains undetermined. Objectives This systematic review aims to present the current status of preclinical and clinical evidence regarding the use of PRP as treatment option for ED. Methods A systematic literature search was conducted using PubMed, Cochrane, and ScienceDirect databases, until February 2023 for studies exploring the effect of PRP on ED. Results We identified 517 articles, 23 of which were included in this review. These were 7 preclinical (of which 1 was a comparative trial and 6 were placebo-controlled randomized controlled trials) and 16 clinical studies (of which 1 was a comparative trial, 5 were randomized trials, and 2 were placebo-controlled randomized controlled trials). Preclinical data support the regenerative role of PRP in erectile tissue, in accordance with existing evidence in other tissues. Randomized clinical studies, as well as the first 2 available randomized, placebo-controlled clinical trials, showed promising efficacy and a lack of any adverse events. Conclusion As PRP for ED is widely used worldwide, there is an urgent need for high-quality studies with long-term follow-up. Standardization of research protocols, especially on the quality of PRP preparation, is also needed.

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Efficacy and Safety of Intracavernosal Injection of Autologous Platelet Rich Plasma for Treatment of Erectile Dysfunction

Cited by 2 publications

References 0 publications

Efficacy and safety of platelet-rich plasma (PRP) in erectile dysfunction (ED): a systematic review and meta-analysis

Efficacy and safety of platelet-rich plasma (PRP) in erectile dysfunction (ED): a systematic review and meta-analysis

Platelet-rich plasma for the treatment of erectile dysfunction: a systematic review of preclinical and clinical studies

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