2024
DOI: 10.1002/art.42993
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Efficacy and Safety of Intravenous Secukinumab in Patients With Active Axial Spondyloarthritis: Results From a Randomized, Placebo‐Controlled, Phase 3 Study

Atul Deodhar,
Jerzy Supronik,
Alan Kivitz
et al.

Abstract: ObjectiveTo assess the efficacy and safety of intravenous (IV) secukinumab for the treatment of adults with active axial spondyloarthritis (axSpA) in INVIGORATE‐1.MethodsINVIGORATE‐1 (NCT04156620) was a randomized, double‐blind, parallel‐group, phase III trial in patients with active axSpA (either radiographic or non‐radiographic). Patients were randomized 1:1 to receive IV secukinumab (6 mg/kg at baseline followed by 3 mg/kg every 4 weeks) or IV placebo for 16 weeks. After Week 16, patients randomized to plac… Show more

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