Efficacy and safety of Lacticaseibacillus paracasei Lpc-37® in students facing examination stress: A randomized, triple-blind, placebo-controlled clinical trial (the ChillEx study)

Mäkelä, Sanna M.; Griffin, Síle M.; Reimari, Jenni; Evans, Kara C.; Hibberd, Ashley A.; Yeung, Nicolas; Ibarra, Alvin; Junnila, Jouni; Turunen, Jari; Beboso, Ronnie; Chhokar, Balgit; Dinan, Timothy G.; Cryan, John; Patterson, Elaine

doi:10.1016/j.bbih.2023.100673

Brain, Behavior, & Immunity - Health

2023

DOI: 10.1016/j.bbih.2023.100673

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Efficacy and safety of Lacticaseibacillus paracasei Lpc-37® in students facing examination stress: A randomized, triple-blind, placebo-controlled clinical trial (the ChillEx study)

Sanna M. Mäkelä,

Síle M. Griffin,

Jenni Reimari

et al.

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2024

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Cited by 1 publication

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Effect of Probiotics Supplementation on Cortisol Levels: A Systematic Review and Meta-Analysis

Jain,

Anand,

Sharma

et al. 2024

Nutrients

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Background: Several randomized controlled trials (RCTs) have shown conflicting results on cortisol levels following probiotic administration in healthy and diseased populations. Previous analyses were inconclusive due to limited studies, and evidence is lacking on how these effects vary by health status; region; therapy duration; medications, and use of single or multiple strains. Methods: In this systematic review and meta-analysis (PROSPERO [CRD42024538539]), we searched PubMed, Cochrane Library, Embase, Scopus, Web of Science, CINAHL, ProQuest, and Web of Science Preprints until 13 August 2024, for RCTs on probiotic administration, either alone or combined, across all age groups and without specific medical condition requirements. We applied random-effects meta-analysis, assessed bias using the Cochrane RoB 2 tool, and evaluated evidence certainty with GRADE. Findings: We screened 1739 records and retrieved 46 RCTs (3516 participants). Probiotics supplementation decreased cortisol levels compared to the control arm [46 RCTs; SMD: −0.45; 95% CI: −0.83; −0.07; I2: 92.5%, low certainty]. Among various subgroups; probiotics supplementation decreased the cortisol levels in the subgroups without concomitant medications [37 RCTs; SMD: −0.30; 95% CI [−0.58; −0.03], I2: 88.7%] with a single probiotic strain [30 RCTs; SMD: −0.33; 95% CI: −0.63; −0.028; I2: 88.8%], in a healthy population [35 RCTs; SMD:−0.3; 95% CI: −0.58; −0.03; I2: 88.7] and in the Asia region [21 RCTs; SMD: −0.83; 95% CI: −1.58; −0.07; I2: 95%]. Interpretation: A low level of evidence suggests probiotics might reduce cortisol levels, but more targeted studies are needed to identify variables affecting the response in specific subgroups.

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Effect of Probiotics Supplementation on Cortisol Levels: A Systematic Review and Meta-Analysis

Jain,

Anand,

Sharma

et al. 2024

Nutrients

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show abstract

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Efficacy and safety of Lacticaseibacillus paracasei Lpc-37® in students facing examination stress: A randomized, triple-blind, placebo-controlled clinical trial (the ChillEx study)

Cited by 1 publication

References 56 publications

Effect of Probiotics Supplementation on Cortisol Levels: A Systematic Review and Meta-Analysis

Effect of Probiotics Supplementation on Cortisol Levels: A Systematic Review and Meta-Analysis

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