Efficacy and safety of laser-assisted delivery of tranexamic acid for the treatment of melasma: a systematic review and meta‑analysis

Feng, Jianfeng; Shen, Sihao; Song, Xiuzu; Xiang, Wenzhong

doi:10.1080/14764172.2022.2148186

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…The patient satisfaction rates typically exceeded the relevant clinical outcomes and were maintained at all time points assessed. These results align with the meta-analysis of five RCTs, which showed that laser modalities combined with TXA significantly decreased the MASI/mMASI scores, while no serious adverse events were observed, except mild erythema and burning pain [43]. The efficacy of LADD will probably render the intradermal tranexamic acid injections alone or combined with Q-switched Nd-YAG laser, though effective, obsolete due to the associated pain from injection despite topical anesthetic cream used [44].…”

Section: Discussionsupporting

confidence: 81%

Laser-Assisted Drug Delivery on the Face: A Systematic Review of Indications and Outcomes

Seretis,

Papaioannou

2023

Cosmetics

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Laser-assisted drug delivery (LADD) has gained prominence as a promising technique with the potential to enhance topical drug skin penetration and absorption. However, the effectiveness of various laser-assisted facial procedures remains unclear. This systematic review aimed to explore and summarize the evidence regarding the indications, clinical outcomes, and adverse effects of LADD performed on the face. Based on a predetermined protocol, an electronic search in MEDLINE, Scopus, the Cochrane Library, and CENTRAL electronic databases was conducted. Eligible studies comprised prospective controlled trials that explored the utility of laser-assisted techniques for topical medication facial application and reported on efficacy and/or safety. Secondary outcomes encompassed patient satisfaction. This review included 12 prospective controlled studies involving a total of 271 participants. LADD, through various laser types, topical medications, clinical protocols, and follow-up assessments, showed enhanced melasma, facial rejuvenation, scar, and periprocedural laser outcomes without increased risk of adverse effects. This review provides evidence that LADD is an effective and safe adjunct for various facial procedures. It also highlights the necessity for further high-quality studies with larger sample sizes, standardized treatment protocols, and evaluation of long-term outcomes and adverse effects in order to elucidate the potential of laser-assisted drug delivery.

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Section: Discussionsupporting

confidence: 81%

Laser-Assisted Drug Delivery on the Face: A Systematic Review of Indications and Outcomes

Seretis,

Papaioannou

2023

Cosmetics

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“…A recent meta‐analysis by Feng et al investigating the effects of tranexamic acid in addition to laser treatment showed similar results, where the inhibitory effect on melanin, as measured by MI, was notable at week 4. However, decreases in MI scores were not as apparent at months 2, 3, and 6 24 …”

Section: Discussionmentioning

confidence: 82%

“…However, decreases in MI scores were not as apparent at months 2, 3, and 6. 24 Epidermal growth factor also plays a crucial role in promoting the proliferation and migration of keratinocytes in the process of dermal wound healing. 10 Researches have been confirmed the efficacy of EGF to accelerate acute wound healing such as superficial seconddegree burn wounds, traumata, and surgical wounds.…”

Section: Discussionmentioning

confidence: 99%

The role of epidermal growth factor‐containing topical products on recovery and post‐inflammatory hyperpigmentation prevention after laser surgeries: A systematic review and meta‐analysis

Ying,

Zhang,

Qiu

et al. 2023

J of Cosmetic Dermatology

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BackgroundPost‐inflammatory hyperpigmentation (PIH) is a common complication after laser surgeries. Recent studies applied epidermal growth factor (EGF) on the lasered area after laser surgery to decrease the incidence of PIH with controversial results. Therefore, a comprehensive literature review of randomized controlled trials (RCTs) was conducted to investigate the issue.MethodsTwo reviewers independently searched the literatures, extracted, and analyzed the data. A total of seven RCTs involving 169 patients were included to evaluate the efficacy of EGF on recovery and PIH prevention after laser surgery.ResultsThe results show that the incidence of PIH in the EGF group was relatively lower than that in the control group, although the difference was not statistically significant (OR 0.64, 95% CI 0.33 ~ 1.25, p = 0.19). However, the EGF groups had a significant decrease in melanin index (MI) scores at the 1st month after the laser surgery when compared to the control groups (SMD −1.57, 95% CI −2.83 ~ −0.31, p = 0.01). In addition, the patients on the EGF side rated significantly higher satisfactory scores (SMD 0.49, 95% CI 0.22 ~ 0.76, p = 0.0004). There was no significant difference as regard to changes in MI at the 2nd week and 2nd month, erythema index (EI), and trans‐epidermal water loss (TEWL) at days 3 and 7 after laser therapy, respectively.ConclusionThe current meta‐analysis found a limited temporary inhibitory effect of EGF‐containing topical products on PIH with no significant effect on reducing post‐laser erythema or promoting epidermal barrier repair. More studies are needed in the future due to the small sample size and marked intergroup heterogeneities.

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Effectiveness of laser and topical tranexamic acid combination therapy in melasma: An updated systematic review and meta-analysis of randomized controlled trials

Khan,

Abdi,

Farkouh

et al. 2023

Lasers Med Sci

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Efficacy and safety of laser-assisted delivery of tranexamic acid for the treatment of melasma: a systematic review and meta‑analysis

Cited by 6 publications

References 23 publications

Laser-Assisted Drug Delivery on the Face: A Systematic Review of Indications and Outcomes

Laser-Assisted Drug Delivery on the Face: A Systematic Review of Indications and Outcomes

The role of epidermal growth factor‐containing topical products on recovery and post‐inflammatory hyperpigmentation prevention after laser surgeries: A systematic review and meta‐analysis

Effectiveness of laser and topical tranexamic acid combination therapy in melasma: An updated systematic review and meta-analysis of randomized controlled trials

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