Efficacy and Safety of Long-Term Losartan Therapy Demonstrated by a Prospective Observational Study in Japanese Patients with Hypertension: The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) Study

Fujita, Toshiro; Ito, Sadayoshi; Ogihara, Toshio; Shimada, Kazuyuki; Shimamoto, Kazuaki; Tanaka, Heizo; Yoshiike, Nobuo

doi:10.1291/hypres.31.295

Cited by 31 publications

(17 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17-19 Losartan, an angiotensin II receptor antagonist, has been shown to reduce serum uric acid through the inhibition of urate transporter 1 in renal tubules. 20, 21 In the present study, even after the exclusion of the subjects with anti-hypertensive or uric acid-lowering treatment, higher blood pressure groups remained associated with higher serum uric acid levels. Although these findings further support the idea that blood pressure is associated with serum uric acid, this association was not found in the subjects taking anti-hypertensive medicine.…”

Section: Discussionmentioning

confidence: 41%

Association of Serum Uric Acid With Blood Pressure in Japanese Men - Cross-Sectional Study in Work-Site Group -

Kansui

Ohtsubo

Gotō

et al. 2011

Circ J

View full text Add to dashboard Cite

Background: It has been reported that elevated levels of serum uric acid are related to hypertension and cardiovascular disease. Recent studies, however, have found little association between hyperuricemia and hypertension. Methods and Results:The association of serum uric acid with blood pressure was examined in 3,960 Japanese male workers (18-64 years of age; mean age, 42.3±0.2 years). Systolic blood pressure was significantly correlated with serum uric acid. Multiple regression analysis also showed that both systolic and diastolic blood pressures were independently associated with serum uric acid. When subjects were divided into 6 groups according to blood pressure on the basis of the Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009), serum uric acid was elevated in a linear fashion as blood pressure increased. A similar relationship was found even in 3,608 subjects who were not taking anti-hypertensive or uric acid-lowering agents. In contrast, no relation was found between serum uric acid and blood pressure in 352 subjects taking anti-hypertensive medicine.Conclusions: Blood pressure is closely associated with serum uric acid. Serum uric acid might be associated with the increase in blood pressure, because there is no relation between serum uric acid and blood pressure in the subjects treated with anti-hypertensive medications. (Circ J 2011; 75: 2827 - 2832

show abstract

Section: Discussionmentioning

confidence: 41%

Association of Serum Uric Acid With Blood Pressure in Japanese Men - Cross-Sectional Study in Work-Site Group -

Kansui

Ohtsubo

Gotō

et al. 2011

Circ J

View full text Add to dashboard Cite

show abstract

“…39 In this study, adherence was substantially high in both therapy groups throughout the observation period (Table 2), which is in line with previous studies demonstrating that losartan and a combination of losartan and a small dose of HCTZ were well tolerated in hypertensive patients. [40][41][42] In addition, BP self-measurements at home might be useful in raising the adherence to hypertensive medications by improving patient motivation. 43 Combination therapy included more male subjects than high-dose therapy (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Losartan/hydrochlorothiazide combination vs. high-dose losartan in patients with morning hypertension—a prospective, randomized, open-labeled, parallel-group, multicenter trial

2012

View full text Add to dashboard Cite

on behalf of the MAPPY Study InvestigatorsThe treatment of morning hypertension has not been established. We compared the efficacy and safety of a losartan/ hydrochlorothiazide (HCTZ) combination and high-dose losartan in patients with morning hypertension. A prospective, randomized, open-labeled, parallel-group, multicenter trial enrolled 216 treated outpatients with morning hypertension evaluated by home blood pressure (BP) self-measurement. Patients were randomly assigned to receive a combination therapy of 50 mg losartan and 12.5 mg HCTZ (n¼109) or a high-dose therapy with 100 mg losartan (n¼107), each of which were administered once every morning. Primary efficacy end points were morning systolic BP (SBP) level and target BP achievement rate after 3 months of treatment. At baseline, BP levels were similar between the two therapy groups. Morning SBP was reduced from 150.3 ± 10.1 to 131.5 ± 11.5 mm Hg by combination therapy (Po0.001) and from 151.0 ± 9.3 to 142.5 ± 13.6 mm Hg by high-dose therapy (Po0.001). The morning SBP reduction was greater in the combination therapy group than in the high-dose therapy group (Po0.001). Combination therapy decreased evening SBP from 141.6±13.3 to 125.3±13.1 mm Hg (Po0.001), and high-dose therapy decreased evening SBP from 138.9 ± 9.9 to 131.4 ± 13.2 mm Hg (Po0.01). Although both therapies improved target BP achievement rates in the morning and evening (Po0.001 for both), combination therapy increased the achievement rates more than high-dose therapy (Po0.001 and Po0.05, respectively). In clinic measurements, combination therapy was superior to high-dose therapy in reducing SBP and improving the achievement rate (Po0.001 and Po0.01, respectively). Combination therapy decreased urine albumin excretion (Po0.05) whereas high-dose therapy reduced serum uric acid. Both therapies indicated strong adherence and few adverse effects (Po0.001). In conclusion, losartan/HCTZ combination therapy was more effective for controlling morning hypertension and reducing urine albumin than high-dose losartan.

show abstract

“…Losartan has a relatively modest uricosuric effect [ 588,813 ] . In large population studies (29,850 subjects), there are relatively few adverse effects associated with losartan therapy [ 840 ] . Only 46 patients in this study experienced major adverse effects including dizziness, electrolyte disturbances, hepatic function abnormalities, headache, anemia, cough, blood creatinine phosphokinase increases, and blood pressure decreases (hypotension).…”

Section: Losartanmentioning

confidence: 99%

Management of Hyperuricemia and Gout

Newcombe¹

2012

Gout

View full text Add to dashboard Cite

Efficacy and Safety of Long-Term Losartan Therapy Demonstrated by a Prospective Observational Study in Japanese Patients with Hypertension: The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) Study

Cited by 31 publications

References 38 publications

Association of Serum Uric Acid With Blood Pressure in Japanese Men - Cross-Sectional Study in Work-Site Group -

Association of Serum Uric Acid With Blood Pressure in Japanese Men - Cross-Sectional Study in Work-Site Group -

Losartan/hydrochlorothiazide combination vs. high-dose losartan in patients with morning hypertension—a prospective, randomized, open-labeled, parallel-group, multicenter trial

Management of Hyperuricemia and Gout

Contact Info

Product

Resources

About