Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis

Melatonin treatment has consistent but transient beneficial effects on sleep measures and pain in patients with severe chronic pain: the DREAM–CP randomised controlled trial

“… 24 , 25 , 26 In patients with migraine, a meta-analysis of three small trials concluded that prophylactic melatonin use reduced the frequency, severity, and duration of migraine compared with placebo but was not superior to amitriptyline. 27 A recent meta-analysis of four small trials showed reduced severity of irritable bowel syndrome after variable durations of melatonin treatment, although sleep was not improved. 28 The doses of melatonin used in these studies were variable; there is no consensus as to what constitutes a clinically effective dose.…”

Cronofarmacología en enfermedades neurológicas

“…Algunos estudios respaldan el uso de melatonina como tratamiento preventivo en la migraña 62 , la cefalea en racimos 63 y, con datos menos consistentes, en la cefalea hípnica 64 .…”