Efficacy and Safety of Modified Radical Mastectomy for Advanced Breast Cancer at Sub Saharan Breast Center, Kampala

Makumbi, Timothy; Fualal, J.; Kilyewala, Cathy; Kintu, L.

doi:10.1016/s0960-9776(19)30714-3

Cited by 1 publication

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“…Of the four retrospective studies, two reported the 5‐year overall and metastasis‐free survival 19,20 . Stage status and histology data were reported and specified in seven; 17–23 among these, five studies reported hormonal status 17–21 . Only one study registered the status of the nodes, 19 and only one another mentioned the axillary dissection 20 .…”

Section: Resultsmentioning

confidence: 99%

Female breast cancer in sub‐Saharan Africa: A PRISMA‐S‐compliant systematic review of surgery

Amouzou

Ketevi

Sambiani

et al. 2021

Journal of Surgical Oncology

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Background In sub‐Saharan countries (SSAs), the advanced stage at diagnosis and the limited surgical interventions of female breast cancer (FBC) lead to poor outcomes. This study assessed current modalities of FBC surgeries. Methods Six literature databases (Medline, Embase, African Journal Online, Google Scholar, Web of Science, Cochrane Library) were searched, plus a manual search, in 2011–2021. We included primary data studies with any setting and presurgeries or postsurgeries treatments, we excluded non‐English language studies, editorials, and grey literature. Results The search yielded 21 observational studies (16 retrospective, 3 prospective, and 2 case reports). Of the total 6900 patients, 4121 (60%) patients underwent FBC surgical excision only, and 751/2779 (27%) conservative surgery (BCS) or therapy (BCT). All studies reported similar use of mastectomy (>60%), the FBC surgical excision/reconstruction studies displayed more neoadjuvant chemotherapy (536/2779, 19% vs. 215/4121, 5%), and radiotherapy or adjuvant radiotherapy (1461/2779, 52% vs. 411/3921, 4%). Patients' age, histological classification, staging, and follow‐up data were often missing. Conclusions The FBC complexity requires structured management by general and plastic surgeons, radiotherapy specialists, and obstetrician‐gynecologists through shared guidelines, protocols, and specific programs of public health. In SSAs, FBC surgical strategies should point at decreasing radical mastectomy and increasing BCS/BCT.

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