Efficacy and safety of motherwort injection add‐on therapy to carboprost tromethamine for prevention of post‐partum blood loss: A meta‐analysis of randomized controlled trials

Abstract

Motherwort (YiMuCao), a traditional Chinese herb, has been shown beneficial effects for women's diseases. This meta-analysis aimed to evaluate the efficacy and safety of motherwort injection add-on therapy to carboprost tromethamine for prevention of post-partum blood loss. A systematic literature search was conducted in PubMed, Embase, Cochrane Library, CNKI, VIP and Wanfang from their inception to December 2017. Randomized controlled trials that determined the add-on effects of motherwort injection to carboprost for prevention of post-partum blood loss were eligible. Pooled risk ratio (RR) and mean difference (MD) with 95% confidence interval (CI) were used to summarize the effect sizes. Eight trials including 1276 pregnant women fulfilled the inclusion criteria. Prophylactic use of motherwort injection add-on therapy significantly reduced the post-partum 2 h (MD −127.5 mL; 95% CI −149.13 to −105.88) and 24 h (MD −146.85 mL; 95% CI −179.77 to −113.94) blood loss and incidence of post-partum hemorrhage (RR 0.28; 95% CI 0.17-0.45) than carboprost. Moreover, adjunctive treatment with motherwort injection significantly decreased the length of the third stage of labor (MD −3.41 min; 95% CI −4.33 to −2.49) and duration of lochia (MD −7.13 days; 95% CI −8.49 to −5.76). There was no statistical significant difference in the incidence of adverse events (RR 0.76; 95% CI 0.50-1.16). Prophylactic use of motherwort injection add-on therapy to carboprost tromethamine could reduce post-partum blood loss. However, more well-designed trials are necessary to confirm the findings of this study due to the methodological flaws of the included trials.

Herbalism for Modern Obstetrics

“…The dose of carboprost tromethamine was 250 μg and the total dose of motherwort injection ranged from 60 to 200 mg. There was no statistically significant difference in the incidence of the most frequently reported adverse events (nausea, vomiting, chest tightness, hypertension, and shivering) between mothers who received carboprost or mortherwort (RR=0.76; 95% CI: 0.50-1.16) 113…”

“…There was no statistically significant difference in the incidence of the most frequently reported adverse events (nausea, vomiting, chest tightness, hypertension, and shivering) between mothers who received carboprost or mortherwort (RR = 0.76; 95% CI: 0.50-1.16). 113 In 2018, Chen and colleagues performed a systematic review and meta-analysis of randomized controlled trials that compared motherwort injection alone or in combination with oxytocin in pregnant women delivered by cesarean. Forty-six trials involving 7359 delivered women were included.…”

The Regulatory Effects of Traditional Chinese Medicine on Ferroptosis

“…In the past, motherwort was considered as a safe and non-toxic TCM. In recent years, accumulating studies have found that long-term and high-dose use of motherwort will cause some adverse reactions, mainly manifested as sudden feeling of general weakness, paralysis of the lower limbs, severe sweating, decreased blood pressure, and rapid breathing, and even cause uterine contractions and lead to miscarriage in pregnant women [ 36 , 37 ].…”

Stachydrine represses the proliferation and enhances cell cycle arrest and apoptosis of breast cancer cells via PLA2G2A/DCN axis

“…Meanwhile, increasing evidences have also highlighted the application of Chinese herbal medicine (CHM), including botanical, animal, and mineral agents, in the treatment of cancers, BC, for instance, by virtue of their valuable pharmacological activities with low toxicity (Sun et al., 2016; Zou et al., 2020). Chinese motherwort (YiMuCao, Leonurus japonicus ) is a traditional Chinese herb showing therapeutic effects for obstetrical and gynecological diseases (Meng et al., 2019; Miao et al., 2019). Among the active compounds, Stachydrine has been widely investigated (Shang et al., 2014).…”