Efficacy and safety of novel topical pigment‐correcting regimen with biweekly diamond tip microdermabrasion procedures on facial hyperpigmentation

Abstract

BackgroundFacial hyperpigmentation can negatively affect an individual's emotional and psychosocial well‐being.AimsAssess safety and tolerability of a combination of microdermabrasion (DG) procedures using a novel brightening pro‐infusion serum (EC‐DG) with a targeted at‐home treatment regimen in subjects with mild to severe facial hyperpigmentation, including melasma, post‐inflammatory hyperpigmentation, and dark spots.Patients/MethodsThis 12‐week, open‐label study enrolled 18 subjects (Fitzpatrick skin types I–IV) who underwent 6 in‐office DG procedures with EC‐DG (one procedure administered biweekly), along with daily topical application of a brightening treatment serum and dark spot cream. End points included change from baseline across multiple skin quality attributes and the Melasma Area and Severity Index (MASI), self‐assessment questionnaires, and tolerability assessments.ResultsThe combination treatment was well tolerated and resulted in significant (p ≤ 0.05) improvements from baseline in radiance, tactile roughness, and moisturization/hydration immediately after the first treatment, in MASI score at day 3, and in overall hyperpigmentation at week 4. Most (94.1%) subjects were satisfied with treatment.ConclusionsDG procedures using EC‐DG combined with a targeted at‐home skincare regimen are effective and tolerable for treating facial hyperpigmentation across a broad range of skin types.