Efficacy and Safety of Oral TDF-Based Pre-exposure Prophylaxis for Men Who Have Sex With Men: A Systematic Review and Meta-Analysis

Huang, Xiaojie; Hou, Jun; Song, Aixin; Liu, Xinchao; Yang, Xiaodong; Xu, Junjie; Zhang, Jing; Hu, Qinghai; Chen, Hui; Chen, Yaokai; Meyers, Kathrine; Wu, Hao

doi:10.3389/fphar.2018.00799

Cited by 58 publications

(38 citation statements)

References 40 publications

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“…Low levels of PrEP awareness have been consistently reported in the Chinese MSM community . Although many studies have demonstrated that oral Tenofovir‐based PrEP regimens are effective and safe among MSM , a considerable proportion of our sample was concerned about PrEP's efficacy (56.8%) and potential side effects (69.9%). These two concerns emerged as more notable barriers to PrEP adoption within our study sample than within other study samples in Asia.…”

Section: Discussionmentioning

confidence: 85%

“…Adjusted ORs for PrEP knowledge and PrEP uptake preferences among men participated in the China MSMs HIV PrEP Uptake Willingness Online Survey, 2017 (N = 4581) PrEP uptake "Definitely yes" AOR (95% CI) "Probably yes" AOR (95% CI) MSM community [30,31]. Although many studies have demonstrated that oral Tenofovir-based PrEP regimens are effective and safe among MSM [37], a considerable proportion of our sample was concerned about PrEP's efficacy (56.8%) and potential side effects (69.9%). These two concerns emerged as more notable barriers to PrEP adoption within our study sample than within other study samples in Asia.…”

Section: Discussionmentioning

confidence: 99%

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PrEP uptake preferences among men who have sex with men in China: results from a National Internet Survey

et al. 2019

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Introduction HIV incidence among men who have sex with men (MSM) is high in China. Pre‐exposure prophylaxis (PrEP) is a promising mean to prevent HIV transmission but it is not widely available in China. We conducted a large Internet‐based online survey to assess the willingness of Chinese MSM to take PrEP and associated factors to their uptake preferences.MethodsBetween 19 January and 6 February, 2017, 4581 MSM aged over 15 years were recruited via a social networking app to take an online PrEP survey. HIV status at the time of the survey being conducted was not one of recruitment criteria. Participants were asked if they had heard of PrEP, if they had concerns about PrEP, and if they would be ready to uptake PrEP should it be provided. When asked if participants were willing to take PrEP, they were asked to select from the following responses: “definitely not,” “probably not,” “not sure,” “probably yes,” and “definitely yes.” In the final analysis, we grouped these five‐level Likert scale responses into three‐level responses as “definitely yes,” “probably yes,” and “no (definitely not/probably not/not sure).” Descriptive analysis and multinomial logistic regressions were conducted to assess the associations of PrEP adoption readiness and uptake concerns with HIV risk behaviours and demographic characteristics.Results MSM from 33 geographical regions of China participated in the survey. The majority were younger than 25 (65.2%) and had attended college (68.6%). HIV prevalence was high (6.8%) and 43.3% reported a history of unprotected anal sex. Only 22.4% of participants had heard of PrEP. When asked if they would uptake PrEP, 26.0% said “definitely yes,” 49.6% were “probably yes,” and 24.4% said “no.” PrEP adoption readiness was associated with having previously heard of PrEP and expressing concerns about accessibility and cost. Worries about side effects, low perceived HIV risk, preference for condoms, and never having received HIV testing were negatively associated with PrEP uptake willingness.ConclusionYoung and well‐educated Chinese MSM reported a low willingness to uptake PrEP despite being high‐risk for HIV. Effective education, especially through online mediums, will be critical to optimize this group's PrEP uptake.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

PrEP uptake preferences among men who have sex with men in China: results from a National Internet Survey

et al. 2019

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“…For each experiment, PBMCs were isolated from fresh blood collected from four healthy HIV-negative donors by density gradient centrifugation. 77 PBMCs were resuspended to 1×10 6 Louis, Missouri, USA) was used as the positive control, at a final concentration of 10 µg/mL. The CCR5-tropic HIV-1 NL4-3 AD8 78 was used at an multiplicity of infection (MOI) of 0.9, as previously described.…”

Section: Materials and Methods Isolation And Culture Of Pbmcs With Hivmentioning

confidence: 99%

Betamethasone induces potent immunosuppression and reduces HIV infection in a PBMC in vitro model

Cromarty

Sigal

Liebenberg

et al. 2021

Journal of Investigative Medicine

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Genital inflammation is an established risk factor for increased HIV acquisition risk. Certain HIV-exposed seronegative populations, who are naturally resistant to HIV infection, have an immune quiescent phenotype defined by reduced immune activation and inflammatory cytokines at the genital tract. Therefore, the aim of this study was to create an immune quiescent environment using immunomodulatory drugs to mitigate HIV infection. Using an in vitro peripheral blood mononuclear cell (PBMC) model, we found that inflammation was induced using phytohemagglutinin and Toll-like receptor (TLR) agonists Pam3CSK4 (TLR1/2), lipopolysaccharide (LPS) (TLR4) and R848 (TLR7/8). After treatment with anti-inflammatory drugs, ibuprofen (IBF) and betamethasone (BMS), PBMCs were exposed to HIV NL4-3 AD8. Multiplexed ELISA was used to measure 28 cytokines to assess inflammation. Flow cytometry was used to measure immune activation (CD38, HLA-DR and CCR5) and HIV infection (p24 production) of CD4+ T cells. BMS potently suppressed inflammation (soluble cytokines, p<0.05) and immune activation (CD4+ T cells, p<0.05). BMS significantly reduced HIV infection of CD4+ T cells only in the LPS (0.98%) and unstimulated (1.7%) conditions (p<0.02). In contrast, IBF had minimal anti-inflammatory and immunosuppressive but no anti-HIV effects. BMS demonstrated potent anti-inflammatory effects, regardless of stimulation condition. Despite uniform immunosuppression, BMS differentially affected HIV infection according to the stimulation conditions, highlighting the complex nature of these interactions. Together, these data underscore the importance of interrogating inflammatory signaling pathways to identify novel drug targets to mitigate HIV infection.

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“…Zahlreiche Studien belegen die Wirksamkeit der PrEP [6][7][8][9]. Seit 2017 existiert im WIR -Walk In Ruhr -Zentrum für sexuelle Gesundheit und Medizin ein innovatives Modellprojekt zur intersektoralen PrEP-Versorgung (.…”

Section: Hiv-präexpositionsprophylaxe-versorgung In Intersektoraler Zunclassified

HIV-Präexpositionsprophylaxe-Versorgung in intersektoraler Zusammenarbeit

Ahaus

Potthoff

Kayser³

et al. 2020

Hautarzt

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Zusammenfassung Hintergrund Zur HIV(„human immunodeficiency virus“)-Präexpositionsprophylaxe (PrEP) wird am WIR – Walk In Ruhr – Zentrum für Sexuelle Gesundheit und Medizin ein innovatives Modellprojekt zur intersektoralen PrEP-Versorgung durchgeführt. Forschungsziele Die vorliegende Studie beschreibt, wer mit der PrEP versorgt wurde und wie sich im Verlauf der PrEP-Einnahme das sexuelle Risikoverhalten änderte sowie welche sexuell übertragbaren Infektionen (STI) und unerwünschte Arzneimittelwirkungen auftraten. Methoden In die Studie wurden bisher N = 139 Probanden eingeschlossen, die zwischen 10/2017 und 12/2018 mit einer PrEP begonnen haben. Alle PrEP-Nutzer erhielten Fragebögen, zudem wurden Nebenwirkungen, HIV und andere STI mittels klinischer Laborwerte über einen Zeitraum von 13 Monaten erfasst. Ergebnisse Die PrEP-Nutzer hatten ein durchschnittliches Alter von 38 Jahren, waren zu 98,6 % Männer, die Sex mit Männern (MSM) hatten, und zeichneten sich durch einen hohen Bildungsstatus und geringe Arbeitslosigkeit aus. Die durchschnittliche Partneranzahl pro Proband innerhalb der letzten 6 Monate stieg im Verlauf signifikant an, während die Kondomnutzung signifikant zurückging. Innerhalb der ersten 4 Monate nach PrEP-Beginn traten 44 STI bei 34 Patienten auf. Es wurde keine HIV-Infektion festgestellt. In den ersten 4 Wochen nach PrEP-Beginn zeigten sich bei 38,8 % der Probanden unerwünschte Arzneimittelwirkungen, hauptsächlich Symptome des Magen-Darm-Trakts. Schlussfolgerung Die PrEP-Nutzer hatten einen guten Bildungsstatus und einen festen Arbeitsplatz bzw. eine Ausbildungsstelle. Das sexuelle Risikoverhalten nahm im Verlauf zu, verbunden mit einem gehäuften Auftreten von STI. Unerwünschte Arzneimittelwirkungen zeigten sich insbesondere zu Anfang der PrEP-Einnahme.

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Efficacy and Safety of Oral TDF-Based Pre-exposure Prophylaxis for Men Who Have Sex With Men: A Systematic Review and Meta-Analysis

Cited by 58 publications

References 40 publications

PrEP uptake preferences among men who have sex with men in China: results from a National Internet Survey

PrEP uptake preferences among men who have sex with men in China: results from a National Internet Survey

Betamethasone induces potent immunosuppression and reduces HIV infection in a PBMC in vitro model

HIV-Präexpositionsprophylaxe-Versorgung in intersektoraler Zusammenarbeit

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