Efficacy and Safety of Oral Propranolol Premedication to Reduce Reflex Tachycardia During Hypotensive Anesthesia With Sodium Nitroprusside in Orthognathic Surgery: A Double-Blind Randomized Clinical Trial

Apipan, Benjamas; Rummasak, Duangdee

doi:10.1016/j.joms.2009.07.065

Cited by 27 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study was in agreement with the study by Apipan et al .,[16] which used oral propranolol premedication during hypotensive anesthesia with nitroprusside in orognathic surgery and concluded that premedication with oral propranolol is safe and effective to reduce reflex tachycardia and the amount of SNP used.…”

Section: Discussionsupporting

confidence: 93%

Effects of preoperative β-blocker on blood loss and blood transfusion during spinal surgeries with sodium nitroprusside-controlled hypotension

Amr

Amin

2012

Saudi J Anaesth

View full text Add to dashboard Cite

Background:The present study sought to determine whether premedication with oral β-blocker before hypotensive anesthesia with sodium nitroprusside could improve the quality of surgical field, decrease the blood loss, and decrease the need for homologous blood transfusion and duration of surgery.Methods:Eighty patients scheduled for spinal fixation surgery were included in a prospective, randomized, double-blinded study. Patients were classified into two groups: Group I received oral atenolol 50 mg twice one day before surgery; and Group II received placebo tablets identical in appearance to atenolol tablets for the same period and interval. All patients in both the groups received intraoperative sodium nitroprusside (SNP) as a hypotensive agent. Hemodynamic variables, amount of sodium nitroprusside used, quality of surgical field, and the amount of homologous blood transfusion and blood loss were compared between groups.Results:Heart rate and amount of SNP used were significantly less (P<0.0001) in the atenolol group, but no significant difference was found in intraoperative mean arterial blood pressure (MABP) between the two groups. The time of surgeries was significantly shorter in Group I than in Group II (185±15.21 vs 225±12.61 min), P<0.0001. The quality of surgical field was better in Group I than in Group II in all times of measurements, P<0.0001. The amount of blood loss and the amount of packed red blood cells transfused were significantly less in Group I than in Group II, P<0.0001. No clinically significant complications were observed in either group.Conclusion:Premedication with oral atenolol 50 mg twice/day for one day before hypotensive anesthesia with SNP during spinal surgeries seems to be clinically safe and effective to reduce heart rate, amount of SNP used, amount of blood loss, and amount of blood transfused with better quality of surgical field.

show abstract

Section: Discussionsupporting

confidence: 93%

Effects of preoperative β-blocker on blood loss and blood transfusion during spinal surgeries with sodium nitroprusside-controlled hypotension

Amr

Amin

2012

Saudi J Anaesth

View full text Add to dashboard Cite

show abstract

“…Endotracheal intubation and reflexes triggered by general anesthesia can cause arrhythmias, reflex hypertension and bleeding, with hematoma formation. Adequate control of these reflexes can be obtained using atenolol, as has been shown in some studies 12,13 . Despite this, we still prefer the technique of local anesthesia with sedation, which proved to be safe and effective.…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 78%

Atenolol prevents the formation of expansive hematoma after rhytidoplasty

Moreira

Moreira²,

Gurgel³

et al. 2014

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

show abstract

“…The oral forms of propranolol and ivabradine are well tolerated, rapidly and completely absorbed from the gastrointestinal tract. The onset of action of the oral forms is within 20-30 min, with peak plasma concentration attained within 60-90 min [28,30].…”

Section: Discussionmentioning

confidence: 99%

Ivabradine versus propranolol given orally in microlaryngoscopic surgeries in attenuating stress response: A comparative prospective double blind randomized study

Ibrahim

Atallah

2016

Egyptian Journal of Anaesthesia

View full text Add to dashboard Cite

Background and objective: In this study we evaluated oral ivabradine (a relatively new heart rate lowering agent) versus oral propranolol (a classic commonly used beta-blocker) in achieving a hemodynamic stability and controlling possible changes in blood glucose level due to stress response in microlaryngoscopic surgeries. Methods: A total of 50 American Society of Anesthesiologists (ASA) 1,2 patients scheduled for microlaryngoscopic surgeries were included in this prospective, randomized controlled double blind study. They were given either oral ivabradine (5 mg tablet) group I or oral propranolol (10 mg tablet) group P in the evening before the operation and 1 h before the induction of anesthesia. Hemodynamic variables (systolic, diastolic, mean blood pressure and heart rate) and blood glucose level were recorded perioperatively. Results: The changes in blood pressure and heart rate in both groups were mild after intubation, laryngoscope fixation for surgery and extubation but these changes in ivabradine group were significantly less than the changes in propranolol group (P < 0.05). No significant difference (P > 0.05) was found between both groups in blood glucose level perioperatively. No statistically significant complications were observed in both groups. Conclusion: Premedication with 5 mg of oral ivabradine or 10 mg of oral propranolol before microlaryngoscopic surgeries was effective in achieving a good degree of hemodynamic stability but ivabradine was more effective. Both drugs didn't show an obvious effect on blood glucose level perioperatively. No complications were recorded.

show abstract

Efficacy and Safety of Oral Propranolol Premedication to Reduce Reflex Tachycardia During Hypotensive Anesthesia With Sodium Nitroprusside in Orthognathic Surgery: A Double-Blind Randomized Clinical Trial

Cited by 27 publications

References 20 publications

Effects of preoperative β-blocker on blood loss and blood transfusion during spinal surgeries with sodium nitroprusside-controlled hypotension

Effects of preoperative β-blocker on blood loss and blood transfusion during spinal surgeries with sodium nitroprusside-controlled hypotension

Atenolol prevents the formation of expansive hematoma after rhytidoplasty

Ivabradine versus propranolol given orally in microlaryngoscopic surgeries in attenuating stress response: A comparative prospective double blind randomized study

Contact Info

Product

Resources

About