Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study

Koh, Young Gue; Seok, Joon; Park, Jae Wan; Kim, Ka Ram; Yoo, Kwang Ho; Kim, Yong Joon; Kim, Beom Joon

doi:10.1016/j.heliyon.2023.e16711

Cited by 4 publications

(6 citation statements)

References 26 publications

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“…Skin moisture measured with the corneometer showed significant increases in all values 4 and 12 weeks after intake, consistent with a previous study by Koh et al [25], which that oral administration of 7-MEGA TM contributed to the prevention of skin aging through hydration in both studies.…”

Section: Discussionsupporting

confidence: 91%

“…Although taking the test food significantly increased the moisture content of the skin itself, oral administration of 7-MEGA TM did not seem to have prevented the increased loss of moisture. In a previous study using a two-meter TM-300, as in this study, the amount of transdermal water loss in the test group decreased, but it was not significant [ 25 ].…”

Section: Discussionmentioning

confidence: 60%

“…An in-vitro study showed that 7-MEGA TM has an anti-inflammatory effect on high sensitivity of human epidermal keratinocyte cells, which promote collagen regeneration in the presence of cytotoxicity caused by hydrogen peroxide, and the anti-inflammatory effect of 7-MEGA TM appears to be mediated through silent information regulator 1 activation [ 24 ]. In addition, a clinical study conducted in humans reported that 7-MEGA TM not only restored skin barrier function but also improved quality of life by safely improving skin elasticity and wrinkles [ 25 ]. Compared to previous studies, we adopted more outcomes, such as wrinkles, melanin index, erythema index, and GPDS, to clarify the efficacy of 7-MEGA TM on skin aging.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGATM: A Randomized, Double-Blind, Placebo Comparative Clinical Trial

Sung,

Kim,

Kim

et al. 2024

Nutrients

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7-MEGATM is a food product made from purified Alaska pollack fish oil containing palmitoleic acid (16:1), commonly referred to as omega-7. We sought to quantitatively evaluate whether this substance inhibits skin aging. A total of 101 middle-aged females were randomly allocated to the intervention (N = 50) or placebo group (N = 51). Each participant was advised to take either 500 mg of 7-MEGATM or a placebo twice daily for 12 weeks. The primary outcomes were the degree of improvement in wrinkles and the degree of moisture filling after consumption for 12 weeks compared to baseline. The secondary outcomes were improvement in skin wrinkles; moisture changes at 4 and 8 weeks from baseline; changes in transdermal water loss, skin elasticity, the melanin index, the erythema index, and the Global Photo Damage Score. We found a significant improvement in skin wrinkles and elasticity at 12 weeks in the 7-MEGATM-consuming group compared to that in the placebo group; skin moisture, elasticity, and the melanin index were also improved. No supplement-related adverse reactions were observed and 7-MEGATM was identified as safe. 7-MEGATM was effective for human skin function in terms of wrinkles, moisture, elasticity, and melanin production and may be useful as a skin nutritional supplement.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGATM: A Randomized, Double-Blind, Placebo Comparative Clinical Trial

Sung,

Kim,

Kim

et al. 2024

Nutrients

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mentioning

confidence: 99%

“…Heart-healthy fatty acids such as (37), especially in combination with polyphenols, can prevent and improve cardiovascular disease [117]. Other unsaturated fatty acids found in B. gasipaes can also ameliorate the effects of MetS [118,119]. Heart-healthy fatty acids such as (37), especially in combination with polyphenols, can prevent and improve cardiovascular disease [117].…”

mentioning

confidence: 99%

Five Underutilized Ecuadorian Fruits and Their Bioactive Potential as Functional Foods and in Metabolic Syndrome: A Review

Duarte-Casar,

González-Jaramillo,

Bailon-Moscoso

et al. 2024

Molecules

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The Ecuadorian Amazon harbors numerous wild and cultivated species used as food, many of which are underutilized. This review explores the bioactive potential of five such fruits—Borojó (Alibertia patinoi); Chonta (Bactris gasipaes); Arazá (Eugenia stipitata); Amazon grape (Pourouma cecropiifolia), a wild edible plant; and Cocona (Solanum sessiliflorum)—and their applications against metabolic syndrome. This study highlights their health-promoting ingredients and validates traditional medicinal properties, emphasizing their significance in improving health and mitigating the effects of the Western diet. These fruits, integral to Ecuadorian cuisine, are consumed fresh and processed. Chonta is widely cultivated but less prominent than in pre-Hispanic times, Borojó is known for its aphrodisiac properties, Cocona is traditional in northern provinces, Arazá is economically significant in food products, and Amazon grape is the least utilized and researched. The fruits are rich in phenolics (A. patinoi, E. stipitata) and carotenoids (B. gasipaes, E. stipitata), which are beneficial in controlling metabolic syndrome. This study advocates for more research and product development, especially for lesser-known species with high phenolic and anthocyanin content. This research underscores the economic, cultural, and nutritional value of these fruits, promoting their integration into modern diets and contributing to sustainable agriculture, cultural preservation, and public health through functional foods and nutraceuticals.

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Therapeutic efficacy and mechanism of solubilized sturgeon oil in a mouse model of house dust mite-induced atopic dermatitis

Lee,

Park

et al. 2024

Journal of Functional Foods

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Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study

Cited by 4 publications

References 26 publications

Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGATM: A Randomized, Double-Blind, Placebo Comparative Clinical Trial

Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGATM: A Randomized, Double-Blind, Placebo Comparative Clinical Trial

Five Underutilized Ecuadorian Fruits and Their Bioactive Potential as Functional Foods and in Metabolic Syndrome: A Review

Therapeutic efficacy and mechanism of solubilized sturgeon oil in a mouse model of house dust mite-induced atopic dermatitis

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