Efficacy and safety of orlistat in male patients with overweight/obesity and hyperuricemia: results of a randomized, double-blind, placebo-controlled trial

Abstract

Background Obesity is associated with elevated serum uric acid (SUA) levels and frequent gout flares. Losing weight can reduce the SUA level and gout flares. The effect of orlistat on SUA levels and gout flares in patients with overweight/obesity and hyperuricemia (HUA) has not been extensively studied. This study investigated the effects of orlistat on SUA levels and gout flares compared to placebo in overweight and obese patients with HUA. Methods A total of 72 Chinese patients with overweight/obesity and HUA were randomly divided into a placebo group (35, 48.6%) and an orlistat group (37, 51.4%); the trial lasted 12 weeks. The primary endpoints were the relative changes in body weight, the SUA level, and gout flares in the per-protocol population. Results Orlistat reduced the proportion of patients with gout flares (log-rank P = 0.023, hazard ratio = 0.31, 95% confidence interval 0.11–0.85). There was no significant difference in SUA level between the two groups. The average weight loss of the orlistat group was 2.85 kg, and the average weight loss of the placebo group was 0.76 kg. The weight loss in the orlistat group was significantly greater than that in the control group (P < 0.05). Conclusions This study is the first to demonstrate that orlistat has no significant effect on SUA levels in patients with overweight/obesity and HUA. The utility of orlistat as an adjunct therapy to prevent gout flares during weight loss in patients with HUA was emphasized. Trial registration Clinicaltrials.gov NCT05496075.

Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

“…Against diabetes, frequently administrated drugs include metformin, insulin, sulfonylureas such as glyburide [ 46 ], glucagon-like peptide-1 (GLP-1) receptor agonists like liraglutide [ 47 ], and sodium–glucose cotransporter 2 (SGLT2) inhibitors such as dapagliflozin [ 48 ]. In the case of anti-obesity drugs, common agents include lipase inhibitors such as orlistat [ 49 ], sympathomimetic appetite suppressants like phentermine [ 50 ], GLP-1 receptor agonists such as semaglutide [ 51 ], and serotonin receptor agonists like lorcaserin [ 52 ].…”