Efficacy and Safety of Pegaspargase, Gemcitabine, Dexamethasone, and Cisplatin Combined Chemotherapy in Newly Diagnosed Extranodal Nk/T Cell Lymphoma

Abstract

done in 5/40 patients on diagnosis. Bone marrow infiltration was detected by PET/CT in 7/35 (20%) and by BMB in 5/35 (14%) cases.There was concordance between PET/CT and BMB in 27 patients (77%), 25 with negative PET/CT and BMB results and 2 with positive PET/CT and BMB results. Discordant results were observed in 8 patients. The sensitivity, specificity, positive predictive value and negative predictive value (NPV) of PET/CT for bone marrow involvement were 40%, 83%, 28.5% and 89%, respectively.Conclusions: Our study shows that 90% of PTCL are FDG avid at baseline, as one would expect with aggressive lymphoma. As the NPV of PET/CT for BM involvement is high, a negative PET/CT rules out bone marrow involvement.