Efficacy and Safety of Pregabalin in Patients with Fibromyalgia and Comorbid Depression Taking Concurrent Antidepressant Medication: A Randomized, Placebo-controlled Study

Arnold, Lesley M.; Sarzi-Puttini, Piercarlo; Arsenault, Pierre; Khan, Tahira; Brown, P. Bhadra; Clair, Andrew; Scavone, Joseph M.; Driscoll, Joseph R.; Landen, Jaren W.; Pauer, L.

doi:10.3899/jrheum.141196

Cited by 35 publications

(31 citation statements)

References 27 publications

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“…A pool analysis of Phase II and III randomized control trials of pregabalin in fibromyalgia found that pregabalin reduced pain and improved sleep quality [57]. A subsequent randomized placebo-controlled trial of pregabalin in 197 patients with fibromyalgia with comorbid depressant and taking concurrent anti-depressants (SNRI or SSRI) [58] also found that pregabalin reduced pain, anxiety and depression as well as improved sleep quality when compared with placebo-treated patients. However, these results were based on patient's report of sleep quality.…”

Section: • Effect Of Snri On Sleepmentioning

confidence: 94%

Current Treatments to Counter Sleep Dysfunction as a Pathogenic Stimulus of Fibromyalgia

Choy

2016

Pain Manag.

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Fibromyalgia is characterized by chronic widespread pain, fatigue and nonrestorative sleep. Polysomnography showed reduced short-wave sleep and abnormal alpha rhythms during nonrapid eye movement sleep in patients with fibromyalgia. However, sleep dysfunction might be pathogenic in fibromyalgia since myalgia and fatigue could be induced in healthy individuals by disrupting sleep. Poor sleep quality was a major risk factor for the subsequent development of chronic widespread pain in healthy pain-free individuals. Sleep disruption leads to impairment of the descending pain inhibition pathways. Aside from good sleep, hygiene, exercise can promote sleep. Among currently available pharmacological treatments, evidence suggests amitriptyline and pregabalin can improve sleep in fibromyalgia.

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Section: • Effect Of Snri On Sleepmentioning

confidence: 94%

Current Treatments to Counter Sleep Dysfunction as a Pathogenic Stimulus of Fibromyalgia

Choy

2016

Pain Manag.

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“…Eleven clinical studies were identified as randomized, double-blind, placebo-controlled, studies [42][43][44][45][46][47][48][49][50][51][52]. Table 1 shows a summary of the studies (see also Table 1 of the Supplemental Online Material for more details of each study).…”

Section: Randomized Double-blind Placebo-controlled Clinical Studiesmentioning

confidence: 99%

An evidence-based review of pregabalin for the treatment of fibromyalgia

Arnold

Choy

Clauw

et al. 2018

Current Medical Research and Opinion

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“…The treatment of pain conditions may be helpful for sleep quality. A randomized placebo-controlled study evaluated the efficacy of pregabalin use, a drug for fibromyalgia treatment, on the management of pain (Arnold et al 2015). Women were more prevalent in this cohort (93%), and the participants were taking antidepressant medication early in the study, such as selective serotonin reuptake inhibitor (SSRI) or serotonin/norepinephrine reuptake inhibitor (SNRI).…”

Section: Sleep and Painmentioning

confidence: 99%

The interfaces between vitamin D, sleep and pain

Oliveira

Hirotsu

Tufik

et al. 2017

Journal of Endocrinology

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The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested its action on different biological mechanisms, such as nociceptive sensitivity and sleep-wake cycle modulation. Sleep is an important biological process regulated by different regions of the central nervous system, mainly the hypothalamus, in combination with several neurotransmitters. Pain, which can be classified as nociceptive, neuropathic and psychological, is regulated by both the central and peripheral nervous systems. In the peripheral nervous system, the immune system participates in the inflammatory process that contributes to hyperalgesia. Sleep deprivation is an important condition related to hyperalgesia, and recently it has also been associated with vitamin

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Efficacy and Safety of Pregabalin in Patients with Fibromyalgia and Comorbid Depression Taking Concurrent Antidepressant Medication: A Randomized, Placebo-controlled Study

Abstract: Compared with placebo, pregabalin statistically significantly improved FM pain and other symptoms in patients taking antidepressant medication for comorbid depression. ClinicalTrials.gov identifier: NCT01432236.

Cited by 35 publications

References 27 publications

Current Treatments to Counter Sleep Dysfunction as a Pathogenic Stimulus of Fibromyalgia

Current Treatments to Counter Sleep Dysfunction as a Pathogenic Stimulus of Fibromyalgia

An evidence-based review of pregabalin for the treatment of fibromyalgia

The interfaces between vitamin D, sleep and pain

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