This study discussed the effect of whole course of comprehensive nursing after the operation for benign prostatic hyperplasia (BPH). Eighty-six patients with BPH who were to undergo prostatic hyperplasia surgery were divided into a control group and a study group based on therapeutic method. 43 patients in each group were postoperatively given usual care in the control group and comprehensive nursing in the study group. The mental status, prostate symptoms, quality of life, complications and degree of satisfaction were compared before and after the interventions. The mental status, prostate symptoms, and quality of life (QOL) of the patients were relatively similar (p > 0.05) before the intervention. The scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS), international prostate symptom scale (IPSS) and QOL of patients in the study group were significantly lower than those in the control group after the intervention (p < 0.05). The incidence of complications in the study group was 4.65%, which was significantly lower than that of the control group at 18.60% (p < 0.05), while the satisfaction rate in the study group was 95.35%, which was significantly higher than that of the control group at 69.77% (p < 0.05) . The whole course of comprehensive nursing after the operation for BPH surgery was effective in improving patients’ mental status, promoting the recovery of prostate, improving patients’ quality of life, reducing the incidence of complications, and improving patients’ satisfaction.