Efficacy and safety of Q-switched lasers for the treatment of naevus of Ota in children: a retrospective analysis

Zhou, Hongmei; Du, Xiao‐Jie; Wang, Zhao; Wang, Zhaoyang; Chen, Ying; Liang, Jingchen; Zhao, Xi; Liu, Jing; Chen, Bin; Zeng, Weihui

doi:10.1007/s10103-023-03724-2

Cited by 2 publications

(7 citation statements)

References 17 publications

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“…This founding was consistent with the reports of Q-switched lasers. 5,13 Notably, we observed an apparent difference in the number of treatment sessions when compared with Yang et al's report. In the study, an average of 79% clearance was achieved after two treatments, compared to a clearance of 55.8% in Yang et al's study.…”

Section: Discussioncontrasting

confidence: 68%

“…Melanosome-targeting Q-switched lasers are currently the main treatment option for nevus of Ota and proved being effective and safe. 3,4,[13][14][15] Zhou et al 13 found that early intervention with a 1064nm Q-switched Nd:YAG laser (QSNL) and a 755nm Q-switched alexandrite laser (QSAL) was beneficial for children with nevus of Ota, which reduced the number of treatments, and achieved a cure rate of 75%-80% after seven treatments, 96.15% after 10 treatments respectively. Achavanuntakul et al 15 initiated the laser treatment with QSNL for children with nevus of Ota before the age of 5 years significantly improved therapeutic outcomes and reduced the risk of adverse events and recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…14,15 Therefore, we recommend that children with nevus of Ota be treated as early as possible, regardless of age. Zhou et al 13 proposed that early intervention would be recommended for patients aged over 1 year, for an elevated risk of recurrence with Q-switched laser treatment in patients under 1 year of age. The validity of their recommendation, however, remains to be elucidated for children receiving picosecond laser treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The rate of recurrence of nevus of Ota in this study was 6.6% compared to the rate of Q-switched laser treatments in children which were reported as 3.8%-15.4% from several retrospective studies. 5,13 Due to different study subjects and designs, it is difficult to determine exactly whether the recurrence rate after the PSAL is lower than those after Q-switched lasers. After the recurrence, two patients received one more PSAL treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Melanosome‐targeting Q‐switched lasers are currently the main treatment option for nevus of Ota and proved being effective and safe 3,4,13–15 . Zhou et al 13 found that early intervention with a 1064nm Q‐switched Nd:YAG laser (QSNL) and a 755nm Q‐switched alexandrite laser (QSAL) was beneficial for children with nevus of Ota, which reduced the number of treatments, and achieved a cure rate of 75%–80% after seven treatments, 96.15% after 10 treatments respectively. Achavanuntakul et al 15 initiated the laser treatment with QSNL for children with nevus of Ota before the age of 5 years significantly improved therapeutic outcomes and reduced the risk of adverse events and recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Picosecond alexandrite laser treatment of nevus of Ota in children

Zhao,

Yang,

Shi

et al. 2024

Lasers Surg Med

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BackgroundThe picosecond alexandrite laser has been safely and effectively used to treat the nevus of Ota in adults. However, limited data are available for children.ObjectiveTo investigate the efficacy, safety, and correlative influencing factors of a 755nm picosecond alexandrite laser in the treatment of nevus of Ota in children.MethodsWe retrospectively analyzed Chinese children with nevus of Ota who received a 755nm picosecond alexandrite laser treatment in a tertiary dermatological hospital.ResultA total of 305 pediatric patients received an average of two treatments achieving an average of 79% pigment clearance. After the first treatment, 22 patients achieved complete clearance (95%–100%), and 72 patients achieved excellent response (75%–94%), with an average initial efficacy of 63% lesion clearance. Treatment at an early age achieved better initial efficacy (0‐ to 12‐month group >1‐ to 6‐year group, 6‐ to 12‐year group). And 0‐ to 12‐month group achieved better final efficacy. More treatment sessions also increased the final efficacy. Both initial efficacy and final efficacy were better when treating a darker lesion. The incidence of complications was 12.1%, with 10.8% being post‐inflammatory hyperpigmentation and 1.3% being hypopigmentation. The rate of recurrence was 6.6%.LimitationRetrospective study.ConclusionA 755nm picosecond alexandrite laser is safe and effective in treating nevus of Ota in children. Younger to initiate treatment, darker lesions, and more treatments are positively associated with better pigmentation clearance.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Picosecond alexandrite laser treatment of nevus of Ota in children

Zhao,

Yang,

Shi

et al. 2024

Lasers Surg Med

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Patchy Dermal Melanocytosis: Differential Diagnosis and Management

Zhu,

Cen,

Chang

et al. 2024

J of Cosmetic Dermatology

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BackgroundNevus of Ito and Mongolian spots are distinct clinical presentations of patchy dermal melanocytosis, characterized by similar dermatological manifestations that can pose diagnostic difficulties for clinicians.AimThis review aims to consolidate current understanding and research advancements on these conditions to facilitate clinical diagnosis, differential diagnosis, and management.MethodsA comprehensive search of databases including PubMed and Google Scholar was conducted, along with an analysis of pertinent literature retrieved from reference lists spanning nearly four decades.ResultsEpidemiological, clinical, and pathological profiles exhibit nuanced differences between the two conditions, with unique expressions under electron microscopy and the regression possibility. It is noteworthy that most Mongolian spots naturally fade with advancing age, in contrast to nevus of Ito, which persist and may potentially evolve into malignant lesions. While picosecond laser treatment has shown greater efficacy than nanosecond lasers, the lower‐energy approach holds particular promise in pediatric cases. The therapeutic landscape for patchy dermal melanocytosis is evolving, shifting from selective photothermal action to photomechanical or subcellular photothermal modalities.ConclusionThis review underscores the importance of meticulous clinical assessment and the potential of innovative therapeutic approaches in managing these conditions.

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Efficacy and safety of Q-switched lasers for the treatment of naevus of Ota in children: a retrospective analysis

Cited by 2 publications

References 17 publications

Picosecond alexandrite laser treatment of nevus of Ota in children

Picosecond alexandrite laser treatment of nevus of Ota in children

Patchy Dermal Melanocytosis: Differential Diagnosis and Management

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