Efficacy and Safety of Rabeprazole in Children (1–11 Years) With Gastroesophageal Reflux Disease

Abstract

Rabeprazole was effective and safe in 1- to 11-year-old children with GERD.

Pediatric Gastroesophageal Reflux Clinical Practice Guidelines

“…Based on these results, a short trial of a PPI is not recommended as a diagnostic test for infants (80). Results from studies in children Several studies, both open‐label and therapeutic RCTs, assessing the effect of PPIs on GERD symptom reduction in children with and without esophagitis, showed that the greatest symptomatic improvement occurs in the first 2 to 4 weeks of PPI administration, suggesting that this duration may be sufficient as a diagnostic test for GERD in this population (81–84) Other treatment trials have used longer courses of PPIs for treatment without assessment of symptom resolution at earlier endpoints so the assessment of a shorter “PPI test” for symptom resolution could not be evaluated (85). Because these studies were not powered to assess symptom resolution at interim time points and because of concern that some patients have persistent symptoms related to inflammation after only 2 to 4 weeks of therapy, a diagnostic trial window of 4 to 8 weeks was chosen by the working group.…”

A Narrative Review on Efficacy and Safety of Proton Pump Inhibitors in Children

“…In three of the studies, PPIs did not show significant difference from ranitidine or alginates in reducing histological alterations ( van der Pol et al, 2011 ). A multicenter, double-blind, parallel-group study showed that rabeprazole is effective in 1- to 11-year-old children with endoscopically/histologically proven GERD randomized to receive a .5 or 1.0 mg/kg rabeprazole for 12 weeks, with further dose adjustment by weight ( Haddad et al, 2013 ). The same authors have additionally determined the efficacy of maintenance treatment with rabeprazole in 1- to 11-year-old children suffering from GERD, showing healing maintenance in 90% of the children ( Haddad et al, 2014 ).…”

Recomendaciones para el diagnóstico y tratamiento de reflujo gastroesofágico en pediatría Grupo de Trabajo de Reflujo Gastroesofágico del Comité Nacional de Gastroenterología Pediátrica

“…12 • Niños mayores con síntomas típicos: se obtuvo mejoría sintomática en las primeras 2 a 4 semanas. 13,14 Algunos pacientes podrían tener síntomas más duraderos relacionados con inflamación (por eso la duración sugerida es de 4-8 semanas). Pacientes con síntomas extraesofágicos: ningún grupo avala su uso, ya que no hay evidencia suficiente.…”