Efficacy and safety of Reduning injection in the treatment of COVID-19: a randomized, multicenter clinical study

Abstract

Background: Reduning injection is a traditional Chinese medicine (TCM) with known efficacy against a variety of viral infections, but there is no data about its efficacy against coronavirus disease 2019 (COVID-19). Methods: To explore the efficacy and safety of Reduning injection in the treatment of COVID-19, a randomized, open-labeled, multicenter, controlled trial was conducted from 12 general hospitals between 2020.02.06 and 2020.03.23. Patients with COVID-19 who met the diagnostic criteria of the "Diagnosis and Treatment Program for Novel Coronavirus Infection Pneumonia (Trial Fifth Edition)". Patients were randomized to routine treatment with or without Reduning injection (20 mL/day for 14 days) (ChiCTR2000029589).The primary endpoint was the rate of achieving clinical symptom recovery on day 14 of treatment.Results: There were 77 and 80 participants in the Reduning and control groups. The symptom resolution rate at 14 days was higher in the Reduning injection than in controls [full-analysis set (FAS): 84.4% vs. 60.0%, P=0.0004]. Compared with controls, the Reduning group showed shorter median time to resolution of the clinical symptoms (143 vs. 313.5 h, P<0.001), shorter to nucleic acid test turning negative (146.5 vs. 255.5 h, P<0.001), shorter hospital stay (14.1 vs. 18.1 days, P<0.001), and shorter time to defervescence (29 vs. 71 h, P<0.001). There was no difference in AEs (3.9% vs. 8.8%, P=0.383).Conclusions: This preliminary trial suggests that Reduning injection might be effective and safe in patients with symptomatic COVID-19.

Traditional Vietnamese medicine Kovir capsule in patients with mild COVID‐19: A double‐blind randomized controlled trial

“…Several herbal/traditional medicines have been investigated for the treatment of mild and severe/critical COVID-19. They come from countries with well-known traditional medicine such as China (Xia et al, 2021;Xiao et al, 2020;Xu et al, 2021;Zhou et al, 2021), India (Devpura et al, 2021;Natarajan et al, 2021;Srivastava et al, 2021), and Iran (Karimi et al, 2021;Valizadeh et al, 2020). These studies showed that herbal medicines could Antitussive treatment 0 (0.0) 4 (12.5) .050…”

Computational modeling predicts potential effects of the herbal infusion “horchata” against COVID-19

“…Molecules like isorhamnetin, quercetin, luteolin, ferulic acid and others which are major components of horchata are also predominant in the Reduning injection, which was recommended in China for the treatment of pneumonia induced by COVID-19 (X. Xu et al, 2021 ). In addition, a similar list of compounds (also including acacetin ( 26 ) and kaempferol) can be found in other traditional medicines used in Chinae to treat COVID-19-induced pneumonia ( Luo et al, 2020 ).…”

A Five-Dimensional Network Meta-Analysis of Chinese Herbal Injections for Treating Acute Tonsillitis Combined With Western Medicine

“…The antipyretic mechanism of RDN might be related to the regulation of biosynthesis as well as sphingolipid metabolism of valine, leucine, and isoleucine (Gao et al, 2020). In addition, RDN was reported to possess anti-inflammatory and antiviral effects (Cao et al, 2015;Xie et al, 2020;Xu et al, 2021), which might work in treating acute tonsillitis. SHL is made from active ingredients of Forsythia suspensa (Thunb.)…”