Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review

Altman, Roy D.; Hackel, Josh; Niazi, Faizan; Shaw, Peter; Nicholls, Mathew

doi:10.1016/j.semarthrit.2018.01.009

Cited by 115 publications

(76 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Repeated courses of I-HA appear to be an effective and safe treatment of K-OA. A 2018 systemic review examined patients treated with recurrent courses of I-HA for up to 25 months and found that the most common side effect of repeated I-HA was joint swelling and arthralgia [54]. HA preparations of various molecular weights are available in North America, and most meta-analysis and systemic reviews lump the various HA preparations together when analyzing the data.…”

Section: Hyaluronic Acid Injectionsmentioning

confidence: 99%

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

Billesberger¹,

Fisher

Qadri

et al. 2020

Pain Research and Management

View full text Add to dashboard Cite

Knee osteoarthritis is a common painful degenerative condition affecting the aging Canadian population. In addition to pain and disability, osteoarthritis is associated with depression, comorbid conditions such as diabetes, and increased caregiver burden. It is predicted to cost the Canadian healthcare system $7.6 billion dollars by 2031. Despite its high cost and prevalence, controversy persists in the medical community regarding optimal therapies to treat knee osteoarthritis. A variety of medications like nonsteroidal anti-inflammatories and opioids can cause severe side effects with limited benefits. Total knee arthroplasty, although a definitive management, comes with risk such as postoperative infections, revisions, and chronic pain. Newer injectable therapies are gaining attention as alternatives to medications because of a safer side effect profile and are much less invasive than a joint replacement. Platelet-rich plasma is beginning to replace the more common injectable therapies of intra-articular corticosteroids and hyaluronic acid, but larger trials are needed to confirm this effect. Small studies have examined prolotherapy and stem cell therapy and demonstrate some benefits. Trials involving genicular nerve block procedures have been successful. As treatments evolve, injectable therapies may offer a safe and effective pathway for patients suffering from knee osteoarthritis.

show abstract

Section: Hyaluronic Acid Injectionsmentioning

confidence: 99%

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

Billesberger¹,

Fisher

Qadri

et al. 2020

Pain Research and Management

View full text Add to dashboard Cite

show abstract

“…The AAOS CPG and coverage decisions do not acknowledge the recently reported economic and medical benefits associated with viscosupplementation (IA HA) use, including (1) delayed time to knee replacement 7 - 9 , (2) reduced pain medication usage (corticosteroids, nonsteroidal anti-inflammatory drugs [NSAIDs], and opioids) 10 , (3) better cost-effectiveness compared with standard-of-care treatments 11 , (4) improved function 9 , and (5) a favorable safety profile 12 - 14 .…”

Section: The Impactmentioning

confidence: 99%

Consequences on Private Insurance Coverage

Vangsness

Adamson

Daley³

2020

Journal of Bone and Joint Surgery

View full text Add to dashboard Cite

“…Note that Ch, Ga and HA were chosen for supplementation therapy; and a probability of their specific e.g. anti-inflammatory action 75 or "inhibition of chondrodegenerative enzymes" 76 would be a priori be the same as for substances taken at random.…”

Section: Glycosaminoglicans In Osteoarthritismentioning

confidence: 99%

Placebo in the guise of evidence-based medications

Jargin¹

2020

Arşiv Kaynak Tarama Dergisi

View full text Add to dashboard Cite

Placebo therapy can be beneficial and ethically justifiable; but it is not a sufficient reason to publish biased information. Certain journals are selecting reliable reports but others are publishing biased materials and rejecting criticism. Publication series of questional reliability are sometimes continued without making references to published comments. Theories have been construed for promotion of some drugs and dietary supplements without proven effectiveness. This review is a collection of examples, when substances with unproven effects and unclear action mechanisms are directly or indirectly presented by professional publications as evidence-based medications. Some of the topics might be not completely clarified, so that arguments provided here can induce a constructive discussion.

show abstract

Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review

Abstract: Repeated courses of IA-HA injections are an effective and safe treatment for knee OA. Repeat courses were demonstrated to maintain or further improve pain reduction while introducing no increased safety risk.

Cited by 115 publications

References 20 publications

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

Consequences on Private Insurance Coverage

Placebo in the guise of evidence-based medications

Contact Info

Product

Resources

About