Efficacy and safety of risperidone in the treatment of elderly patients suffering from organic brain disease (organic brain syndrome): results from a double-blind, randomized, placebo-controlled clinical trial

Greenspan, Andrew; Schreiner, A.

doi:10.1007/s00213-007-0747-6

Cited by 9 publications

(1 citation statement)

References 11 publications

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“…27 Striatal 5HT 2A receptor inhibition effectively increases available DA, which may account for the lower risk of EPS with risperidone, and data suggest risperidone carries a relatively low short-term risk of inducing EPS in late-onset AD. 28 In this case, 5HT 2A receptor inhibition may nonetheless have been insufficient to overcome potent striatal D 2 blockade by risperidone. Compromised D 2 -receptor function may account for early or severe EPS described in some FAD patients, but characterization of D 2 -receptor function in FAD remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Prominent Neuroleptic Sensitivity in a Case of Early-onset Alzheimer Disease due to Presenilin-1 G206A Mutation

Cercy

Sadowski²,

Wısnıewskı³

2008

Cognitive and Behavioral Neurology

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Objective We describe atypical motor and cognitive features in a case of familial Alzheimer disease (FAD) due to presenilin-1 (PS-1) mutation. Background Extrapyramidal signs (EPS) typically are a late-presenting feature of sporadic Alzheimer disease (AD), but relatively little data are available regarding EPS in FAD. Method A 59-year-old, right-handed man of Caribbean-Hispanic descent underwent brain imaging studies, laboratory tests for AD, and serial neurologic and neuropsychologic evaluations. Results The patient presented with recent-onset delusional ideation associated with cognitive decline. Prominent EPS developed soon after initiation of an atypical neuroleptic agent. Neuropsychologic evaluation revealed global cognitive deficits; he was found to be a carrier of a PS-1 point mutation at position G206A. EPS resolved completely after discontinuing the neuroleptic agent and coincided with improved motor speed, set initiation, and verbal fluency. Conclusions Severe neuroleptic sensitivity and associated deficits of cognitive speed occurred in response to a dopaminergic antagonist agent; both responded readily to withdrawal of the offending agent. Patients with PS-1 AD may be at substantially increased risk of neuroleptic-induced EPS. That feature underscores the heterogeneity of the FAD clinical phenotype.

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Section: Discussionmentioning

confidence: 99%

Prominent Neuroleptic Sensitivity in a Case of Early-onset Alzheimer Disease due to Presenilin-1 G206A Mutation

Cercy

Sadowski²,

Wısnıewskı³

2008

Cognitive and Behavioral Neurology

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Efficacy and Comparative Effectiveness of Atypical Antipsychotic Medications for Off-Label Uses in Adults

Maher¹,

Maglione²,

Bagley³

et al. 2011

JAMA

521

400

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Benefits and harms vary among atypical antipsychotic medications for off-label use. For global behavioral symptom scores associated with dementia in elderly patients, small but statistically significant benefits were observed for aripiprazole, olanzapine, and risperidone. Quetiapine was associated with benefits in the treatment of generalized anxiety disorder, and risperidone was associated with benefits in the treatment of obsessive-compulsive disorder; however, adverse events were common.

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Drug therapy for delirium in terminally ill adults

Finucane

Jones

Leurent

et al. 2020

Cochrane Database of Systematic Reviews

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Efficacy and safety of risperidone in the treatment of elderly patients suffering from organic brain disease (organic brain syndrome): results from a double-blind, randomized, placebo-controlled clinical trial

Cited by 9 publications

References 11 publications

Prominent Neuroleptic Sensitivity in a Case of Early-onset Alzheimer Disease due to Presenilin-1 G206A Mutation

Prominent Neuroleptic Sensitivity in a Case of Early-onset Alzheimer Disease due to Presenilin-1 G206A Mutation

Efficacy and Comparative Effectiveness of Atypical Antipsychotic Medications for Off-Label Uses in Adults

Drug therapy for delirium in terminally ill adults

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