Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis

Zhou, Sheng; Hu, Haiying; Ru, J. Alexander de

doi:10.1016/j.heliyon.2023.e18356

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e18356

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Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis

Sheng Zhou

Haiying Hu²,

J. Alexander de Ru

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2024

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Cited by 3 publications

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Sugammadex for our little ones: a brief narrative review

Lee,

Chung

2024

Anesth Pain Med

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Sugammadex, the first noncompetitive antagonist developed for the reversal of neuromuscular blockade (NMB), is one of the few drugs that has revolutionized anesthetic practice. However, the use of sugammadex for children between the ages of 2 and 17 years has only recently been approved and is currently not approved for children under the age of 2 years. Although the precision and reliability of reversal of NMB with sugammadex are of great benefit in pediatric anesthesia, several important questions remain regarding its use in our youngest patients. In this brief narrative review, we aim to provide an overview of the key considerations and potential challenges that anesthesiologists often face when using sugammadex in pediatric patients.

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Sugammadex for our little ones: a brief narrative review

Lee,

Chung

2024

Anesth Pain Med

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Pediatric airway management: A narrative review of the current practices and challenges

Choudhary,

Singh,

Kumar

2024

Journal of Indira Gandhi Institute of Medical Sciences

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Pediatric patients are more susceptible to critical events, the management of their airway necessitates skilled and meticulous interventions. Thus, it is essential to be well versed with the knowledge that can aid in our understanding of the pediatric airway. We conducted a narrative review of the current understanding of pediatric airway assessment techniques, various airway adjuncts and devices, the use of video laryngoscopes for endotracheal intubation and future trends. The databases Ovid, Medline, PubMed, Web of Science, and Google Scholar were searched regarding various aspects of pediatric airway management from 2005 to 2024. The search terms were pediatric or infant difficult airway, pediatric difficult airway, apneic oxygenation, and pediatric airway assessment. One hundred articles were deemed relevant by abstract, and their full text was obtained and examined further for compliance, and finally, 40 full-text articles were included in the study. This article discusses the various challenges of pediatric anesthesia related to airway management, emphasizing the need for individualized perioperative methods due to children’s unique anatomical and physiological features.

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Sugammadex vs Neostigmine, a Comparison in Reversing Neuromuscular Blockade: A Narrative Review

Maqusood,

Bele,

Verma

et al. 2024

Cureus

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The use of neuromuscular blocking agents (NMBA) has grown due to the development of laparoscopic and minimally invasive procedures. Respiratory insufficiency, an elevated risk of aspiration, postoperative pulmonary complications, and subsequent reintubation are among the risks linked to the residual block. The normal clinical practice calls for the pharmacologic "reversal" of these agents with either sugammadex or neostigmine prior to extubation. The administration of neostigmine is linked to a number of potential complications. In response, anaesthesiologists have begun to prescribe sugammadex more frequently for treating residual block and reversing blockade with NMBA. This review article compares and assesses neostigmine and sugammadex thoroughly in order to determine the extent to which they work as agents to reverse neuromuscular blockade. The review's findings highlight sugammadex's considerable advantages -Sugammadex's ability to quickly and reliably achieve desired train-of-four (TOF) ratios -over neostigmine in reversing neuromuscular blockade in a variety of surgical settings. In contrast, neostigmine's limitations regarding efficacy and rate of reversal were consistently noted in all of the reviewed studies, despite the fact that it is still widely used due to its lower cost and extensive clinical experience. Sugammadex is a superior option for reversing neuromuscular blockade, but incorporating it into standard clinical practice necessitates carefully weighing its potential benefits and drawbacks. Sugammadex provides notable benefits over neostigmine in terms of speed, predictability, and safety.

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Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis

Cited by 3 publications

References 40 publications

Sugammadex for our little ones: a brief narrative review

Sugammadex for our little ones: a brief narrative review

Pediatric airway management: A narrative review of the current practices and challenges

Sugammadex vs Neostigmine, a Comparison in Reversing Neuromuscular Blockade: A Narrative Review

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