2021
DOI: 10.2147/ott.s309285
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Efficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma

Abstract: Aim: Alterations in circadian rhythms caused by tumor growth are thought to be clinically relevant as they affect the prognosis and treatment response. We aimed to evaluate the chronotherapeutic approach in rats with ovarian cancer receiving cisplatin intravenously (IV) or with hyperthermic intraperitoneal chemoperfusion (HIPEC) and to assess daily variations in tumor and intestinal epithelium proliferation. Methods: In the pilot study, we used 12 intact rats and 12 rats with transplantable ovarian cancer, whi… Show more

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Cited by 4 publications
(2 citation statements)
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“…The evidence-based fact that certain chemotherapeutic agents induce fewer side effects when administered at night while others are more efficient on tumour cells when given daytime, should be sufficiently convincing to take the necessary steps to regard chronotherapy as the fourth dimension of oncological treatment [64]. For instance, a recent study on the efficacy and safety of cisplatin chronotherapy in rats with ovarian carcinoma reported less toxicity with the morning administration of the drug as compared to evening chemotherapy, including nephrotoxicity, liver toxicity and gastrointestinal toxicity [65]. This observation confirms the results of other chronotherapy studies on the platinum toxicity profile, where morning cisplatin led to less severe peripheral neuropathy as compared to evening treatment [66].…”
Section: Discussion and Future Prospectsmentioning
confidence: 99%
“…The evidence-based fact that certain chemotherapeutic agents induce fewer side effects when administered at night while others are more efficient on tumour cells when given daytime, should be sufficiently convincing to take the necessary steps to regard chronotherapy as the fourth dimension of oncological treatment [64]. For instance, a recent study on the efficacy and safety of cisplatin chronotherapy in rats with ovarian carcinoma reported less toxicity with the morning administration of the drug as compared to evening chemotherapy, including nephrotoxicity, liver toxicity and gastrointestinal toxicity [65]. This observation confirms the results of other chronotherapy studies on the platinum toxicity profile, where morning cisplatin led to less severe peripheral neuropathy as compared to evening treatment [66].…”
Section: Discussion and Future Prospectsmentioning
confidence: 99%
“…Chronotherapy was explored in melanoma, 29 colorectal, 30 , 31 ovarian cancer, 32 , 33 breast cancer, 34 , 35 non-small-cell lung carcinoma, 36 nasopharyngeal carcinoma, 37 , 38 and glioblastoma 18 , 39 with varying conclusions. Time-dependent administration of treatment in patients with non-small-cell lung carcinoma, 36 melanoma 29 and rats with ovarian cancer 40 prolonged their survival. However, in patients with colorectal cancer, the timed drug administration improved outcomes only of males.…”
Section: Introductionmentioning
confidence: 99%