Efficacy and Safety of TachoSil ® as Haemostatic Treatment versus Standard Suturing in Kidney Tumour Resection: A Randomised Prospective Study

Siemer, Stefan; Lahme, Sven; Altziebler, Stefan; Machtens, S.; Strohmaier, Walter; Wechsel, Hans-W.; Goebell, Peter J.; Schmeller, N. T.; Oberneder, R.; Stolzenburg, Jens‐Uwe; Becker, H.; Lüftenegger, Werner; Tetens, Vilhelm; Poppel, Hendrik Van

doi:10.1016/j.eururo.2007.04.027

Cited by 141 publications

(92 citation statements)

References 27 publications

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“…Tagliabue et al [19] used TachoSil® in patients suffering from severe clotting disturbances in order to perform successful splenectomy and nephrectomy. Some other uses of the coated patch have also been reported: hepatic surgery (liver resection, liver transplantation), urologic surgery (kidney tumor resection, repair of recurrent vesicovaginal fistula), cardiovascular surgery (reduction of postoperative pericardial effusions after aortic tube grafts, in addition to stitches to facilitate mechanical and biologic suture in aortic arch aneurysm repair), digestive surgery (gastrointestinal anastomoses), and neurosurgery (management of cerebrospinal fluid leak after surgical removal of pituitary adenomas) [20][21][22][23][24][25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Nohuz¹,

Darcha

Moreno³

et al. 2009

Gynecol Surg

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The aim of this study was to evaluate the effectiveness of a fibrinogen and thrombin-coated hemostatic sponge (TachoSil®) in the prevention of postsurgical adhesions in a laparoscopic rat model and its histological effects on uterine and peritoneal parenchyma. Design was a prospective randomized blinded study. Setting was in International Laparoscopic Surgery Centre, ClermontFerrand, France. There were 100 sexually mature female Sprague-Dawley rats weighing 240 to 300 g and aged 6-8 weeks. A standardized severe surgical injury induced by scissors and 40-W bipolar coagulation in the rat uterine horn, corpus, and peritoneum was performed to induce adhesion formation. After trauma, group 1 (n=50) received no treatment and group 2 rats (n=50) received TachoSil® applied on injured areas. Twelve weeks after the procedure, repeat laparoscopy was performed and adhesions were scored according to their extent and severity. A hysterectomy and a peritoneal biopsy in the injured area were achieved by laparotomy in order to investigate on a possible earlier effect of TachoSil® on the uterine and peritoneal parenchyma in 49 rats of each group. TachoSil® group adhesion scores showed a significant decrease on the three injured areas: peritoneum (12.96 vs. 21.66), uterine horn (7.22 vs. 15.20), and uterine corpus (5.88 vs. 34.52). TachoSil® group also demonstrated a major decline of uterine fibrosis and inflammation. This study revealed that TachoSil®, an absorbable biomaterial, can reduce postoperative adhesions after laparoscopic surgery on a rat model. TachoSil® also prevents thermo-induced injuries on uterine parenchyma (less fibrosis and less inflammation).

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Section: Discussionmentioning

confidence: 99%

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Nohuz¹,

Darcha

Moreno³

et al. 2009

Gynecol Surg

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“…Upon direct contact with body fluids, the fibrinogen-thrombin reaction forms a fibrin clot that allows the collagen patch adhere to the tissue surface. It has found applications for several different surgical fields, including hemostasis and bile sealing in liver surgery and hemostasis in kidney tumor resection (5,6). Regarding general thoracic surgery, the use of TachoSil ® following pulmonary resection not only reduces the air leak volume, but also allows an early removal of chest drains and an early discharge (7).…”

Section: Discussionmentioning

confidence: 99%

Chylothorax after mediastinal ganglioneuroma resection treated with fibrin sealant patch: a case report

et al. 2017

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Chylothorax is a severe condition resulting from the accumulation of chyle into the pleural space.We report the treatment of postoperative chylothorax after resection of mediastinal ganglioneuroma in a 17-year-old boy. Since conservative measures were not effective, we performed direct ligation of lymphatic vessels and pleurodesis. At subsequent surgical re-exploration for persisting chylothorax, accurate inspection of pleural cavity revealed residual chyle leakage. Fibrin sealant patches (TachoSil ® ) were placed over the source of leak with complete resolution of chylous effusion. To our knowledge, this is the first report of postoperative chylothorax successfully treated by the use of a fibrin sealant patch.

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“…9 There is strong evidence supporting the use of TachoSil ® in kidney surgery. 10,11 Comparator products such as FloSeal, 12,13 Quixil 14,15 and Beriplast P 16,17 are supported by evidence in other areas of surgery, but TachoSil ® is the only product supported by randomised controlled trials in the kidney surgery setting. Randomised controlled trials have also shown the effectiveness of TachoSil ® in liver 7 and lung 18 surgery.…”

Section: Discussionmentioning

confidence: 99%

Kidney salvage using the fibrinogen- and thrombin-coated sponge TachoSil<SUP>®</SUP> during nephron-sparing surgery for the resection of large renal tumours

Attar

Namasivayam²,

Green³

et al. 2008

Ann R Coll Surg Engl

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Efficacy and Safety of TachoSil ® as Haemostatic Treatment versus Standard Suturing in Kidney Tumour Resection: A Randomised Prospective Study

Cited by 141 publications

References 27 publications

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Chylothorax after mediastinal ganglioneuroma resection treated with fibrin sealant patch: a case report

Kidney salvage using the fibrinogen- and thrombin-coated sponge TachoSil<SUP>®</SUP> during nephron-sparing surgery for the resection of large renal tumours

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