Efficacy and safety of the traditional herbal medication Chai-Ling-Tang (in China), Siryung-tang (in Republic of Korea) or Sairei-To (in Japan)

Bailly, Christian

doi:10.1016/j.jep.2023.117127

Cited by 5 publications

(1 citation statement)

References 168 publications

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“…Plant‐based remedies are extensively engaged in managing conditions such as inflammatory disorders, central nervous system diseases, cancer, viral infections, fungal ailments, and various other health issues. 1 Through experimental and clinical investigations, the use of natural products and herbal extracts for treating human diseases and disorders has finally begun to get scientific acceptance. 2 Most developing countries, particularly those in Asia, Africa, Latin America, and the Middle East, rely on traditional medicine, including herbal medicines, to fulfill the primary healthcare requirements and concerns of the rural people.…”

Section: Introductionmentioning

confidence: 99%

Exploring therapeutic potential of Woodfordia fruticosa (L.) Kurz leaf and bark focusing on antioxidant, antithrombotic, antimicrobial, anti‐inflammatory, analgesic, and antidiarrheal properties

Rahman,

Soma,

Sultana

et al. 2023

Health Science Reports

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Background and AimsThe study aimed to evaluate the pharmacological properties of methanolic extracts of leaves and barks of Woodfordia fruticosa (L.) Kurz (family: Lythraceae) focusing on antioxidant, thrombolytic, anti‐inflammatory, antibacterial, analgesic, and antidiarrheal effects.Methods1,1‐Diphenyl‐2‐picrylhydrazyl (DPPH) free radical scavenging assay, clot lysis, disc diffusion, and membrane stabilizing methods were employed to assess in vitro antioxidant, thrombolytic, antibacterial, and anti‐inflammatory properties of the leaf and bark methanolic extracts (ME) of W. fruticosa and different organic solvents, that is, petroleum ether (PE), dichloromethane (DCM), chloroform (CL), and aqueous (AQ) fractions. In addition, in vivo central and peripheral analgesic and antidiarrheal activities of both crude extracts were evaluated at two doses (200 and 400 mg/kg of body weight [bw]).ResultsAll the extracts and fractions showed promising antioxidant properties by scavenging DDPH free radicals with IC50 of 6.11–20.79 μg/mL. AQ fraction (41.24%) of leaves and ME (44.90%) of bark exerted notable in vitro thrombolytic activity. The CL fraction of leaves and AQ fraction of the bark showed 43.16% and 45.37% inhibition of RBC hemolysis, respectively, compared to the inhibition of RBC hemolysis by aspirin in a hypotonic‐induced membrane stabilizing assay. Besides, both extracts were observed to provide significant (p < 0.001) central and peripheral analgesic responses at both doses of 200 and 400 mg/kg bw. Furthermore, both doses of bark extract (p < 0.001) and the 400 mg/kg bw of leaf extract (p < 0.05) were observed to possess statistically significant antidiarrheal activity. Additionally, in an in vivo acute toxicity investigation, both extracts had a median lethal dose (LD50) greater than 5000 mg/kg bw, indicating their safety level.ConclusionThe current study proves the ethnomedicinal uses of W. fruticosa; however, further studies are required for phytochemical screening to isolate the responsible bioactive compounds and discover the lead molecules from the plant species.

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Section: Introductionmentioning

confidence: 99%

Exploring therapeutic potential of Woodfordia fruticosa (L.) Kurz leaf and bark focusing on antioxidant, antithrombotic, antimicrobial, anti‐inflammatory, analgesic, and antidiarrheal properties

Rahman,

Soma,

Sultana

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

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Evaluation of Anti‐Inflammatory and Immunosuppressant Potential of Isotelekin in Lipopolysaccharide (LPS) Stimulated Macrophage (RAW 264.7) and Sheep Red Blood Cells (SRBC) Sensitized Murine Models

Qasam,

Nawaz,

Kumari

et al. 2024

Advanced Biology

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The present study explored the natural compound Isotelekin isolated from Inula racemose against anti‐inflammatory and immunomodulatory potential in LPS‐induced RAW264.7 cell lines and immune‐elevated SRBC‐sensitized animal models. Isotelekin in in vitro studies, inhibited the production of Th‐1 cytokines Interleukin‐6 (IL‐6), Tumour necrosis factor (TNF‐α), and Interferon‐gamma (INF‐γ), and increased Th‐2 cytokines Interleukin‐10 (IL‐10). Whereas it inhibited the nitrites and reactive oxygen species (ROS) production by mitigating the effect of LPS significantly. In vivo immunomodulatory activity in Delayed‐type hypersensitivity (DTH) and Hemagglutinating antibody (HA), Isotelekin suppressed the cellular as well as humoral immunity in immune‐affected and SRBC‐sensitized mice. Isotelekin decreased the phagocytic responses against carbon particles and plaque‐forming mainly IgG (Immunoglobulin G) production. Additionally, Isotelekin showed immunosuppressive potential through the evaluation of splenocytes, allograft acceptance, and haematological parameters. Molecular studies, including western blot analysis and immunocytochemistry, revealed that Isotelekin reduced the expression of iNOS (Inducible nitric oxide synthase), COX‐2 (Cyclo‐Oxygenase 2), and p‐IkBα (Phospho I‐kappa‐B‐alpha), and significantly inhibited the nuclear translocation of NF‐κB/p65. Based on these results, Isotelekin at 10 µm in in vitro and at 30 mg kg−1 in in vivo demonstrated strong anti‐inflammatory and immunosuppressive therapeutic potential.

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Short-term impact of kampo goreisan in patients with congestive heart failure refractory to tolvaptan-incorporated medical therapy

Hida,

Imamura,

Onoda

et al. 2024

Heart Vessels

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Efficacy and safety of the traditional herbal medication Chai-Ling-Tang (in China), Siryung-tang (in Republic of Korea) or Sairei-To (in Japan)

Cited by 5 publications

References 168 publications

Exploring therapeutic potential of Woodfordia fruticosa (L.) Kurz leaf and bark focusing on antioxidant, antithrombotic, antimicrobial, anti‐inflammatory, analgesic, and antidiarrheal properties

Exploring therapeutic potential of Woodfordia fruticosa (L.) Kurz leaf and bark focusing on antioxidant, antithrombotic, antimicrobial, anti‐inflammatory, analgesic, and antidiarrheal properties

Evaluation of Anti‐Inflammatory and Immunosuppressant Potential of Isotelekin in Lipopolysaccharide (LPS) Stimulated Macrophage (RAW 264.7) and Sheep Red Blood Cells (SRBC) Sensitized Murine Models

Short-term impact of kampo goreisan in patients with congestive heart failure refractory to tolvaptan-incorporated medical therapy

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