Efficacy and Safety of the Coadministration of Tadalafil Once Daily with Finasteride for 6 Months in Men with Lower Urinary Tract Symptoms and Prostatic Enlargement Secondary to Benign Prostatic Hyperplasia

Abstract

The coadministration of tadalafil/finasteride provides early improvement in lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement. Tadalafil/finasteride coadministration also improves erectile function in men who have comorbid erectile dysfunction.

Comparative Study of Tadalafil and Tamsulosin as on therapy For Lower Urinary Tract Symptoms Due To Benign Hyperplasia of Prostate.

“…Recently, data on the combination of tadalafil with finasteride (a 5α-reductase inhibitor) have been published 25 . IPSS improvement is significantly higher in the combination group compared with the finasterideonly group at the .…”

Treatment of benign prostatic hyperplasia

“…Combination therapy, compared to finasteride alone, showed patient improvement, but not an overall impression of clinical improvement. 30 (A) Therefore, the addition of tadalafil to finasteride may moderately improve urinary symptoms in men with BPH. 30 (A) The addition of tadalafil to finasteride cannot increase the response to treatment clinically significantly at week 26, based on a post hoc secondary analysis of the RCT described above.…”

“…31 (B) In a subgroup analysis, also part of this study, including 404 sexually active men, tadalafil plus finasteride was associated with a higher score for erectile function compared to finasteride alone (p<0.001 for all moments analyzed). 30 …”

Evolución en el tratamiento médico de los síntomas del tracto urinario bajo en hombres

“…Casabé et al desarrollaron un estudio para evaluar la combinación de finasteride y tadalafil 49 . Sus resultados mostraron una reducción del IPSS mayor para la combinación que para la monoterapia con finasteride a lo largo de las 26 semanas del estudio, que inicialmente fue de 1.7 puntos y hacia el final fue de 1.…”