Efficacy and safety of the compound Chinese medicine SaiLuoTong in vascular dementia: A randomized clinical trial

Jia, Jianping; Wei, Cuibai; Chen, Shuoqi; Li, Fangyu; Tang, Yi; Qin, Wei; Shi, Lu; Gong, Min; Xu, Hui; Li, Fang; He, Jia; Song, Haiqing; Yang, Shanshan; Zhou, Aihong; Wang, Fen; Zuo, Xianbo; Chu, Changbiao; Liang, Junhua; Jia, Longfei; Gauthier, Serge

doi:10.1016/j.trci.2018.02.004

Cited by 34 publications

(55 citation statements)

References 30 publications

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“…The SLT formula consists of standard extracts of specific dosages of Panax ginseng C. A. Meyer (ginseng), Gingko biloba L. (ginkgo), and Crocus sativus L. (saffron). The chemical profile and ratio of the three herbal extracts had been determined and studied in detail previously [ 10 , 11 ]. The cognitive enhancing effect of SLT has been demonstrated in both preclinical and clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Endothelium‐Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery

Yeon

Seto

Chan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Sailuotong (SLT) is a standardized three-herb formulation consisting of extracts of Panax ginseng, Ginkgo biloba, and Crocus sativus for the treatment of vascular dementia (VaD). Although SLT has been shown to increase cerebral blood flow, the direct effects of SLT on vascular reactivity have not been explored. This study aims to examine the vasodilatory effects of SLT and the underlying mechanisms in rat isolated tail artery. Methods. Male (250–300 g) Wistar Kyoto (WKY) rat tail artery was isolated for isometric tension measurement. The effects of SLT on the influx of calcium through the cell membrane calcium channels were determined in Ca2+-free solution experiments. Results. SLT (0.1–5,000 μg/ml) caused a concentration-dependent relaxation in rat isolated tail artery precontracted by phenylephrine. In the contraction experiments, SLT (500, 1,000, and 5,000 μg/mL) significantly inhibited phenylephrine (0.001 to 10 μM)- and KCl (10–80 mM)-induced contraction, in a concentration-dependent manner. In Ca2+-free solution, SLT (500, 1,000, and 5,000 μg/mL) markedly suppressed Ca2+-induced (0.001–3 mM) vasoconstriction in a concentration-dependent manner in both phenylephrine (10 μM) or KCl (80 mM) stimulated tail arteries. L-type calcium channel blocker nifedipine (10 μM) inhibited PE-induced contraction. Furthermore, SLT significantly reduced phenylephrine-induced transient vasoconstriction in the rat isolated tail artery. Conclusion. SLT induces relaxation of rat isolated tail artery through endothelium-independent mechanisms. The SLT-induced vasodilatation appeared to be jointly meditated by blockages of extracellular Ca2+ influx via receptor-gated and voltage-gated Ca2+ channels and inhibition of the release of Ca2+ from the sarcoplasmic reticulum.

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Section: Introductionmentioning

confidence: 99%

Endothelium‐Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery

Yeon

Seto

Chan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Through in vivo and in vitro studies, various components of herbal medicine have been found to possess the ability to intervene in aging-related diseases by activating telomerase, increasing antioxidant capacity, reducing apoptosis and anti-inflammatory activities, and regulating aging-related pathways and exosomes. We also summarized the clinical randomized controlled trials (RCTs) of herbal medicine in the treatment of aging-related diseases ( Table 3) [240][241][242][243][244][245][246][247][248][249][250]. These trials found that herbal medicine displays certain clinical efficacy in the treatment of agerelated diseases such as type 2 diabetes, vascular dementia, AD, and atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…A few clinical studies on AMD exist, but this disorder is considered to be related to the special technique used for intravitreal administration when treating macular lesions. Of note, as shown in Table 3, there are some adverse reactions in the clinical use of herbal medicines, including gastrointestinal discomfort, dry mouth, and abnormal alanine aminotransferase [245][246][247]250]. Experimental studies had also found that there was a dose-response curve characterized by stimulation at a low dose and inhibition at a high dose.…”

Section: Discussionmentioning

confidence: 99%

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Liu

Wei-liang

Gao

et al. 2019

Oxidative Medicine and Cellular Longevity

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Aging is a progressive disease affecting around 900 million people worldwide, and in recent years, the mechanism of aging and aging-related diseases has been well studied. Treatments for aging-related diseases have also made progress. For the long-term treatment of aging-related diseases, herbal medicine is particularly suitable for drug discovery. In this review, we discuss cellular and molecular mechanisms of aging and aging-related diseases, including oxidative stress, inflammatory response, autophagy and exosome interactions, mitochondrial injury, and telomerase damage, and summarize commonly used herbals and compounds concerned with the development of aging-related diseases, including Ginkgo biloba, ginseng, Panax notoginseng, Radix astragali, Lycium barbarum, Rhodiola rosea, Angelica sinensis, Ligusticum chuanxiong, resveratrol, curcumin, and flavonoids. We also summarize key randomized controlled trials of herbal medicine for aging-related diseases during the past ten years. Adverse reactions of herbs were also described. It is expected to provide new insights for slowing aging and treating aging-related diseases with herbal medicine.

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“…However, chemical or growth factor based anti-aging compounds may raise unexpected side effects 25 . On the other hand, the safety of herbal medicine used for designing of cosmetic products is highly acceptable 26,27 . In this study, high passage of HDFs exhibited delayed cell growth rate accompanied by increase of p53 and SA-β-gal.…”

Section: Discussionmentioning

confidence: 99%

Involvement of 8-O-acetylharpagide for Ajuga taiwanensis mediated suppression of senescent phenotypes in human dermal fibroblasts

Hsu

Lin²,

Leu

et al. 2020

Sci Rep

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Herbal medicines are attractive agents for human care. In this study, we found that the alcohol extract of Ajuga taiwanensis (ATE) screened from a chemical bank exhibited potent capacity for suppressing senescence associated biomarkers, including SA-β-gal and up-regulated p53 in old human dermal fibroblasts (HDFs) without induction of significant cytotoxicity up to 100 µg/ml. Concomitantly, cells re-entered the cell cycle by reducing G1 phase arrest and increasing cell growth rate. The ATE was further partitioned to obtain the sub-fractions of n-butanol (BuOH), ethyl acetate (EA) and water. The BuOH and water sub-fractions exhibited less effects on prohibition of cell growth than the EA sub-fraction. All of these sub-fractions exhibited the ability on suppressing SA-β-gal and p53 of old HDFs as low as 5–10 µg/ml. Under the activity guided fractionation and isolation, a major active constituent named AT-1 was isolated. The AT-1 was further identified as 8-O-acetylharpagide by structural analysis, and it could suppress SA-β-gal and p53 of old HDFs below 10 µM. In addition, the intracellular reactive oxygen species (ROS) levels of old HDFs were suppressed by ATE, the sub-fractions of BuOH and water, and AT-1. However, the EA sub-fraction showed little ability on suppression of ROS. Furthermore, we performed an in vivo study using aging mice to be fed with ATE and the sub-fractions followed by immunohistochemical (IHC) staining. The expression of p53 and SA-β-gal was significantly reduced in several tissue sections, including skin, liver, kidney, and spleen. Taken together, current data demonstrated that A. taiwanensis could suppress cellular senescence in HDFs, and might be used for health care.

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Efficacy and safety of the compound Chinese medicine SaiLuoTong in vascular dementia: A randomized clinical trial

Cited by 34 publications

References 30 publications

Endothelium‐Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery

Endothelium‐Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Involvement of 8-O-acetylharpagide for Ajuga taiwanensis mediated suppression of senescent phenotypes in human dermal fibroblasts

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