Efficacy and safety of traditional plant-based medicines for preventing chronic oxaliplatin-induced peripheral neurotoxicity in patients with colorectal cancer: A systematic review and meta-analysis with core herb contribution

Han, Jierong; Lai, Hengzhou; Li, Wenyuan; Liao, Huarui; Xiao, Chong; Li, Xueke; You, Fengming; Guo, Jing

doi:10.1016/j.jep.2024.117735

Cited by 3 publications

(2 citation statements)

References 63 publications

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“…Various studies have demonstrated that herbal medicines containing Astragalus in combination with chemotherapy increased the tumor remission rate, reduced chemotherapy-related side effects such as neutropenia, anemia, nausea, vomiting, and neu-rotoxicity, and enhanced the quality of life of patients with CRC compared to chemotherapy alone [175,176]. Two additional studies on APS combined with FOLFOX4 demonstrated similar effectiveness [177,178]. Shenqi Fuzheng Injection is a Chinese herbal formula consisting of Astragalus and Codonopsis.…”

Section: Malignant Tumors Of the Digestive Systemmentioning

confidence: 99%

Anticancer Mechanism of Astragalus Polysaccharide and Its Application in Cancer Immunotherapy

He,

Liu,

Qin

et al. 2024

Pharmaceuticals

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Astragalus polysaccharide (APS) derived from A. membranaceus plays a crucial role in traditional Chinese medicine. These polysaccharides have shown antitumor effects and are considered safe. Thus, they have become increasingly important in cancer immunotherapy. APS can limit the spread of cancer by influencing immune cells, promoting cell death, triggering cancer cell autophagy, and impacting the tumor microenvironment. When used in combination with other therapies, APS can enhance treatment outcomes and reduce toxicity and side effects. APS combined with immune checkpoint inhibitors, relay cellular immunotherapy, and cancer vaccines have broadened the application of cancer immunotherapy and enhanced treatment effectiveness. By summarizing the research on APS in cancer immunotherapy over the past two decades, this review elaborates on the anticancer mechanism of APS and its use in cancer immunotherapy and clinical trials. Considering the multiple roles of APS, this review emphasizes the importance of using APS as an adjunct to cancer immunotherapy and compares other polysaccharides with APS. This discussion provides insights into the specific mechanism of action of APS, reveals the molecular targets of APS for developing effective clinical strategies, and highlights the wide application of APS in clinical cancer therapy in the future.

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Section: Malignant Tumors Of the Digestive Systemmentioning

confidence: 99%

Anticancer Mechanism of Astragalus Polysaccharide and Its Application in Cancer Immunotherapy

He,

Liu,

Qin

et al. 2024

Pharmaceuticals

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“…Dihydroartemisinin combined with capecitabine enhances anticancer efficacy and alleviates capecitabine-induced diarrhea, immunosuppression, and inflammation [ 172 ], and additionally synergistically enhances the cytotoxicity of oxaliplatin in colon cancer [ 173 ]. Atractylodes macrocephala used in conjunction with oxaliplatin for CRC treatment alleviates oxaliplatin-induced nausea, vomiting, and neurotoxicity [ 174 , 175 ]. Xiaochai Hu decoction mitigates delayed-onset diarrhea induced by irinotecan by increasing beneficial gut flora abundance and reducing inflammation [ 176 ].…”

Section: Tcms With Anti-crc Effects Through Tlr4 Signaling Pathwaymentioning

confidence: 99%

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Luo,

Zhang,

et al. 2024

Molecules

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The toll-like receptor 4 (TLR4) signaling pathway constitutes an intricate network of protein interactions primarily involved in inflammation and cancer. This pathway triggers intracellular signaling cascades, modulating transcription factors that regulate gene expression related to immunity and malignancy. Previous studies showed that colon cancer patients with low TLR4 expression exhibit extended survival times and the TLR4 signaling pathway holds a significant role in CRC pathogenesis. In recent years, traditional Chinese medicines (TCMs) have garnered substantial attention as an alternative therapeutic modality for CRC, primarily due to their multifaceted composition and ability to target multiple pathways. Emerging evidence indicates that specific TCM products, such as andrographolide, rosmarinic acid, baicalin, etc., have the potential to impede CRC development through the TLR4 signaling pathway. Here, we review the role and biochemical processes of the TLR4 signaling pathway in CRC, and natural products from TCMs affecting the TLR4 pathway. This review sheds light on potential treatment strategies utilizing natural TLR4 inhibitors for CRC, which contributes to the advancement of research and accelerates their clinical integration into CRC treatment.

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Integrating UHPLC-Q-TOF-MS/MS, network pharmacology, bioinformatics and experimental validation to uncover the anti-cancer mechanisms of TiaoPi AnChang decoction in colorectal cancer

Guo,

Yuan,

Huang

et al. 2024

Journal of Ethnopharmacology

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Efficacy and safety of traditional plant-based medicines for preventing chronic oxaliplatin-induced peripheral neurotoxicity in patients with colorectal cancer: A systematic review and meta-analysis with core herb contribution

Cited by 3 publications

References 63 publications

Anticancer Mechanism of Astragalus Polysaccharide and Its Application in Cancer Immunotherapy

Anticancer Mechanism of Astragalus Polysaccharide and Its Application in Cancer Immunotherapy

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Integrating UHPLC-Q-TOF-MS/MS, network pharmacology, bioinformatics and experimental validation to uncover the anti-cancer mechanisms of TiaoPi AnChang decoction in colorectal cancer

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