Efficacy and Safety of Traditional Chinese Medicine Based on the Method of “Nourishing Kidney and Clearing Heat” as Adjuvant in the Treatment of Diabetes Mellitus Patients with Periodontitis: A Systematic Review and Meta-Analysis

Jin, Wenqin; Li, Lingfeng; Ai, Huangping; Jin, Zhao; Zuo, Yi

doi:10.1155/2022/3853303

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Previous studies have suggested that traditional Chinese medicine has an anti-inflammatory function in periodontitis and simultaneously improves alveolar bone remodeling [10][11][12]. In the clinic, many traditional Chinese medicine formulas for treating periodontitis contain Asarum and Angelica.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanism of the Asarum–Angelica Drug Pair in the Treatment of Periodontitis Based on Network Pharmacology and Experimental Verification

Chen,

Wang,

Shi

et al. 2023

IJMS

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(1) To examine the potential mechanism of the Asarum–Angelica drug pair against periodontitis and provide an experimental basis for the treatment of periodontitis with herbal medicine. (2) The core components and core targets of the Asarum–Angelica drug pair in the treatment of periodontitis were detected according to network pharmacology methods. Finally, the effect of the Asarum–Angelica drug pair on osteogenic differentiation was observed in mouse embryonic osteoblast precursor cells. (3) According to the results of network pharmacology, there are 10 potential active ingredients in the Asarum–Angelica drug pair, and 44 potential targets were obtained by mapping the targets with periodontitis treatment. Ten potential active ingredients, such as kaempferol and β-sitosterol, may play a role in treating periodontitis. Cell experiments showed that the Asarum–Angelica drug pair can effectively promote the expression of osteoblast markers alkaline phosphatase (ALP), Runt-related Transcription Factor 2 (RUNX2), and BCL2 mRNA and protein in an inflammatory environment (p < 0.05). (4) Network pharmacology effectively analyzed the molecular mechanism of Asarum–Angelica in the treatment of periodontitis, and the Asarum–Angelica drug pair can promote the differentiation of osteoblasts.

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Section: Introductionmentioning

confidence: 99%

Molecular Mechanism of the Asarum–Angelica Drug Pair in the Treatment of Periodontitis Based on Network Pharmacology and Experimental Verification

Chen,

Wang,

Shi

et al. 2023

IJMS

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Effects of Ginsenosides on Periodontal and Orthodontic Gingivitis

Liu,

Dai,

Chang

et al. 2024

j biobased mat bioenergy

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After orthodontic treatment, gingivitis can cause swelling, pain, bleeding, and other symptoms, which significantly compromise gum health and reduce the quality of life. Clinically, dental plaque removal is considered an effective treatment strategy for gingivitis. However, controlling plaque formation for an extended period through mechanical removal is challenging. Current treatment options include Western medicine treatment and drug nursing, but solely relying on Western medicine antibiotics does not effectively prevent gum inflammation and damage in the long run. Additionally, the withdrawal of medication results in a high recurrence rate of up to 30%, which negatively impacts prognosis. In traditional Chinese medicine theory, gingivitis belongs to the category of “dental declaration”. The main syndrome identified is incandescence of stomach fire, characterized by manifestations such as burning gingiva, bleeding, swelling, and pain caused by weakened fire and inflammation. The pathogenesis is closely related to the fluctuations in kidney qi and gastrointestinal dysfunction. Traditional Chinese medicine treatment focuses on clearing stomach and purging fire. Glycyrrhiza Xiexin Decoction contains ginseng, Radix glycyrrhiza, coptis and other traditional Chinese medicines. These drugs contain active ingredients, such as ginsenosides, which have been proven antibacterial effects and the ability to regulate neutrophils and lymphocytes, participate in anti-inflammatory and immune responses, and enhance overall immunity. Clinical trials have demonstrated that the application of glycyrrhiza Xiexin decoction in orthodontic gingivitis significantly enhances clinical efficacy, improves the periodontal status and inflammatory response of patients, reduces the pain of patients, and lowers the recurrence rate. The active ingredients in glycyrrhiza Xiexin decoction, including ginsenosides, effectively reduce the levels of tumor necrosis factor-α (TNF-α), soluble intercellular adhesion molecule-1 (sICAM-1) and nitric oxide (NO), exerting anti-inflammatory effects. Therefore, this study suggests that the active ingredients in glycyrrhiza Xiexin decoction have a significant impact on periodontal health and inflammatory factors in patients with orthodontic gingivitis.

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The Effect of the Root Bark of Lycium chinense (Lycii Radicis Cortex) on Experimental Periodontitis and Alveolar Bone Loss in Sprague-Dawley Rats

Yang,

Song,

Lee

et al. 2024

Antioxidants

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Lycii Radicis Cortex (LRC), the dried root bark of Lycium chinese Mill., has traditionally been used as a medicinal herb in East Asia to treat fever and hyperhidrosis. In the present study, we investigated the effects of LRC extract on ligation-induced experimental periodontitis and associated alveolar bone loss in rats. Twenty-four hours after ligation placement, LRC was orally administered once daily for 10 days. Firstly, LRC administration inhibited anaerobic bacterial proliferation and inflammatory cell infiltration in gingival tissues. Additionally, LRC exhibited anti-inflammatory effects by reducing the expression of inflammatory mediators, including prostaglandin E2, interleukin-1β, and tumor necrosis factor-α. LRC treatment also downregulated mRNA expression of these inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells by inhibiting the mitogen-activated protein kinases and nuclear factor-κB (NF-κB) signaling pathways. Furthermore, LRC showed an antioxidant effect by decreasing the malondialdehyde level and inducible nitric oxide synthase activity in gingival tissues. Moreover, LRC effectively prevented the connective tissue degradation by inhibiting matrix metalloproteinase-8 expression and the loss of collagen-occupied areas in gingival tissues. LRC also decreased the receptor activator of NF-κB ligand/osteoprotegerin (RANKL/OPG) ratio, as well as the number and occupied areas of osteoclasts on the alveolar bone surface, thereby inhibiting alveolar bone loss. In summary, these findings suggest that LRC is a promising medicinal herb for alleviating periodontitis and related alveolar bone loss through its antimicrobial, anti-inflammatory, and antioxidant properties.

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Efficacy and Safety of Traditional Chinese Medicine Based on the Method of “Nourishing Kidney and Clearing Heat” as Adjuvant in the Treatment of Diabetes Mellitus Patients with Periodontitis: A Systematic Review and Meta-Analysis

Cited by 3 publications

References 14 publications

Molecular Mechanism of the Asarum–Angelica Drug Pair in the Treatment of Periodontitis Based on Network Pharmacology and Experimental Verification

Molecular Mechanism of the Asarum–Angelica Drug Pair in the Treatment of Periodontitis Based on Network Pharmacology and Experimental Verification

Effects of Ginsenosides on Periodontal and Orthodontic Gingivitis

The Effect of the Root Bark of Lycium chinense (Lycii Radicis Cortex) on Experimental Periodontitis and Alveolar Bone Loss in Sprague-Dawley Rats

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