Efficacy and safety of tranexamic acid in acute haemorrhage

Franchini, Massimo; Focosi, Daniele; Zaffanello, Marco; Mannucci, Pier Mannuccio

doi:10.1136/bmj-2023-075720

Cited by 2 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, tranexamic acid inhibits fibrinolysis rather than targeting coagulation factors, and the rule of thumb does seem to apply. Fibrinolysis has been described as “a natural mechanism of defence against thrombus formation,” 12 but this teleological view might be mistaken. People with a genetic deficiency of the key fibrinolytic enzyme plasminogen do not seem to experience excess thrombotic events.…”

Section: Risk Of Thrombosis Is Not Increasedmentioning

confidence: 99%

Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems

Roberts,

Murphy,

Moonesinghe

et al. 2024

BMJ

View full text Add to dashboard Cite

Section: Risk Of Thrombosis Is Not Increasedmentioning

confidence: 99%

Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems

Roberts,

Murphy,

Moonesinghe

et al. 2024

BMJ

View full text Add to dashboard Cite

Assessment of Structural and Process Readiness for Postpartum Haemorrhage Care in Uganda and Ghana: A Mixed Methods Study

Tancred,

Weeks,

Mubangizi

et al. 2024

BJOG

View full text Add to dashboard Cite

ObjectiveTo determine structural and process readiness for postpartum haemorrhage (PPH) care at referral‐level facilities in Ghana and Uganda to identify opportunities for strengthening.DesignMixed‐methods cross‐sectional study.SettingThree districts in Ghana and two in Uganda.Population or SampleNine hospitals in Ghana and seven in Uganda; all hospitals had theoretical capacity for caesarean section and blood transfusion.MethodsWe deployed a modular quantitative health facility assessment to explore structural readiness (drugs, equipment, staff) complemented by in‐depth interviews with maternity health service providers to understand process readiness (knowledge, attitudes, and practices as related to World Health Organization [WHO] guidance on PPH care).Main Outcome MeasuresAvailability of essential structural components needed to support key PPH processes of care.ResultsIn both countries, there was generally good structural readiness for PPH care. However, key common gaps included inadequate staffing (especially specialist physicians), and unavailability of blood for transfusion. Interviews highlighted particularly good process readiness in the provision of uterotonics, recognising and responding to retained placenta, and repairing tears. However, there were clear gaps in the utilisation of tranexamic acid and uterine balloon tamponade.ConclusionsWe have identified good structural and process readiness across both Ghanaian and Ugandan health facilities to support PPH responses. However, some key missed opportunities—to align with current WHO guidance on providing bundles of interventions for PPH care—could be strengthened with minimal investment but promising impact.

show abstract

Efficacy and safety of tranexamic acid in acute haemorrhage

Cited by 2 publications

References 53 publications

Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems

Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems

Assessment of Structural and Process Readiness for Postpartum Haemorrhage Care in Uganda and Ghana: A Mixed Methods Study

Contact Info

Product

Resources

About