Efficacy and safety of treating anogenital warts with intralesional vitamin D3 injection: a report on 20 Egyptian patients

Tawfik, Yasmin M; Hosny, Ahmed; El-Gazzar, Amira F; Bakr, Radwa M

doi:10.4103/azmj.azmj_161_19

Cited by 3 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistently, Aktas ¸et al treated single or multiple plantar warts with intralesional vitamin D3 in 20 patients, of whom 2 Dermatologic Terapy 80% showed complete resolution [9]. Nevertheless, intralesional vitamin D appears not to be as efective for anogenital warts [18]. Topical vitamin D3 (maxacalcitol) was frst successfully used by Imagawa and Suzuki for the treatment of refractory warts in 17 patients, including four adults and 13 pediatric patients.…”

Section: Discussionmentioning

confidence: 96%

Topical Calcipotriol for the Treatment of Cutaneous Warts: An Assessor‐Blind Randomized Placebo‐Controlled Trial

Kazeminejad

Bodaghi

Hajheydari

et al. 2023

Dermatologic Therapy

View full text Add to dashboard Cite

Background. Cutaneous warts are common epidermal proliferations caused by human papillomavirus (HPV). We aimed to determine the safety and efficacy of topical calcipotriol for the treatment of cutaneous warts. Methods. This assessor-blind randomized placebo-controlled trial included 56 patients with cutaneous warts referred to a dermatology clinic from January 21 to March 20, 2020. Patients were randomized into two groups (n = 28). One group received calcipotriol 0.05% ointment twice a day on the lesions with a uniform thickness of 1 mm, and the other group received a placebo. The duration of treatment was twomonths, which continued for another two months if resolution did not occur. The primary outcome was complete response to treatment evaluated four months after the initiation of therapy. Secondary outcomes were the number and size of warts assessed at 1, 2, and 4 months and adverse events, including erythema, pruritus, burning sensation, and scaling. Results. Patients in both groups were comparable regarding previous treatment, underlying disease, and disease duration. However, patients in the control group were older. Also, a higher proportion of patients in the calcipotriol group were male and had warts on their palms and toes. Moreover, a higher percentage of controls had moderate disease. The mean number and the size of lesions did not differ between groups before intervention; however, both were significantly lower in the calcipotriol group than in controls at 1st, 2nd, and 4th months. In addition, complete response to treatment was significantly higher in the calcipotriol group (85.7% vs. 16%; P < 0.001 ). On the other hand, the frequency of adverse events was not different between groups ( P = 0.352 ). Conclusions. Calcipotriol can be considered a safe and effective treatment option for cutaneous warts. Trial Registration: This trial is registered with IRCT20170818035762N2, available at https://www.irct.ir/trial/45716.

show abstract

Section: Discussionmentioning

confidence: 96%

Topical Calcipotriol for the Treatment of Cutaneous Warts: An Assessor‐Blind Randomized Placebo‐Controlled Trial

Kazeminejad

Bodaghi

Hajheydari

et al. 2023

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…They found a complete clearance rate of only 11% and concluded that the efficacy of intralesional vitamin D injection for anogenital warts may not be as much as its benefits in treating extragenital ones. 21 It is interesting that intralesional injection of vitamin D might lead to simultaneous clearance of warts at distant areas following immunotherapy. This phenomenon is known as "field effect" and can be especially beneficial in patients with multiple and inaccessible warts.…”

Section: E T T E R T O T H E E D I T O R Vitamin D and Hpv Infection:...mentioning

confidence: 99%

Vitamin D and HPV infection: Clinical pearls

Aryanian,

Balighi,

Goodarzi

et al. 2024

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Cryotherapy alone versus cryotherapy followed by intralesional vitamin D3 in treatment of anogenital warts: a randomized comparative clinical study

Azab,

Nada,

El Azab

et al. 2023

Journal of the Egyptian Women's Dermatologic Society

View full text Add to dashboard Cite

Background Anogenital warts (AGW) have an important impact on quality of life since they cause discomfort and shame. AGW cannot be effectively treated with a single technique. Objective To compare effectiveness and safety of intralesional vitamin D3 injection and cryotherapy in the treatment of AGW. Patients and methods A randomized comparative clinical study included patients with AGW attending to dermatology, Venerology and andrology clinics, Suez Canal University hospitals, Ismailia, Egypt. 36 patients were divided randomly into 2 groups, group A, included 18 patients who were treated with cryotherapy alone and group B that included 18 patients who were treated with cryotherapy then 0.25–1 ml of intralesional vitamin D3 injection in the same session. Results Complete response was obtained in 55.6% versus 94.4% of patients and clinical recurrence occurred in 27.9% versus 5.6% of patients in group A and B respectively (P<0.05). There was significant improvement in number and size of warts in group B more than group A (P<0.05). Conclusion The clinical response of combination of intralesional vitamin D3 as an immune therapy and cryotherapy as an ablative therapy for treatment of AGW is significantly higher than cryotherapy alone with lower recurrence rates and tolerable side effects.

show abstract

Efficacy and safety of treating anogenital warts with intralesional vitamin D3 injection: a report on 20 Egyptian patients

Cited by 3 publications

References 1 publication

Topical Calcipotriol for the Treatment of Cutaneous Warts: An Assessor‐Blind Randomized Placebo‐Controlled Trial

Topical Calcipotriol for the Treatment of Cutaneous Warts: An Assessor‐Blind Randomized Placebo‐Controlled Trial

Vitamin D and HPV infection: Clinical pearls

Cryotherapy alone versus cryotherapy followed by intralesional vitamin D3 in treatment of anogenital warts: a randomized comparative clinical study

Contact Info

Product

Resources

About