Efficacy and Safety of Tribendimidine Against Clonorchis sinensis

Qian, Men-Bao; Yap, Peiling; Yang, Yue; Hai, Liang; Jiang, Zhihua; Li, Wei; Tan, Ye; Zhou, Hui; Utzinger, Jürg; Zhou, Xiao‐Nong; Keiser, Jennifer

doi:10.1093/cid/cis1011

Cited by 55 publications

(33 citation statements)

References 22 publications

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“…A new drug, tribendimidine, appears as effective as praziquantel for clonorchiasis with fewer side-effects (113) . A recent phase two clinical trial demonstrated cure rates up to 91·5% in adults, and up to 98·5% in children in O. viverrini infections treated with 400mg and 100mg of tribendimidine, respectively (114) .…”

Section: For Clonorchis Sinensis Opisthorchis Viverrini and Opisthormentioning

confidence: 99%

Human liver flukes

Harrington

Lamberton

McGregor

2017

The Lancet Gastroenterology & Hepatology

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Section: For Clonorchis Sinensis Opisthorchis Viverrini and Opisthormentioning

confidence: 99%

Human liver flukes

Harrington

Lamberton

McGregor

2017

The Lancet Gastroenterology & Hepatology

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“…Tribendimidine, artemether and artesuante showed high effectiveness in C. sinensis -infected rats and in vitro and hence might be potential new drug candidates for treating infections [183]. Recently, the Chinese anthelmintic drug tribendimidine was demonstrated to be highly effective against human infections [184]. …”

Section: Resultsmentioning

confidence: 99%

Water-Related Parasitic Diseases in China

Tian

Qin

et al. 2013

IJERPH

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Water-related parasitic diseases are directly dependent on water bodies for their spread or as a habitat for indispensable intermediate or final hosts. Along with socioeconomic development and improvement of sanitation, overall prevalence is declining in the China. However, the heterogeneity in economic development and the inequity of access to public services result in considerable burden due to parasitic diseases in certain areas and populations across the country. In this review, we demonstrated three aspects of ten major water-related parasitic diseases, i.e., the biology and pathogenicity, epidemiology and recent advances in research in China. General measures for diseases control and special control strategies are summarized.

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“…Massive drug administration still counts on single drug, praziquantel [27], but no standardized principles of management are yet available. Additionally, tribendimidine, which shows promising efficiency against C. sinensis infection in vivo , in vitro , and in small field test, is expected to be further evaluated [28-30]. …”

Section: Discussionmentioning

confidence: 99%

Time to tackle clonorchiasis in China

2013

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Recent publication of the global epidemiology of clonorchiasis and its relationship with cholangiocarcinoma in the journal of Infectious Diseases of Poverty has stressed the importance of Clonorchis sinensis infection. To further demonstrate its threat on public health, especially in China, comparisons between clonorchiasis and hepatitis B are made in terms of epidemiology, clinical symptoms and carcinogenicity, disability, as well as changing trends. Furthermore, major problems and prioritized researches are argued, from basic biology to intervention. Imbalance between the majority of infected population and the minority of researches in China urges for more work from Chinese scientists and international cooperation.

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Efficacy and Safety of Tribendimidine Against Clonorchis sinensis

Cited by 55 publications

References 22 publications

Human liver flukes

Human liver flukes

Water-Related Parasitic Diseases in China

Time to tackle clonorchiasis in China

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