Efficacy and safety of Tripterygium glycosides in Sjögren’s syndrome treatment: evidence from 12 randomized controlled trials

Luo, Yue; Zhang, Ying; Kuai, Le; Xing, Meng; Ru, Yi; Luo, Ying; Liu, Liu; Chen, Jiale; Li, Bin; Li, Xin

doi:10.21037/apm-21-256

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Consequently, extensive immunosuppression is required for LN, which can lead to serious side effects [8]. Numerous ingredients extracted from Chinese herbs, such as taraxasterol [30], radix astragali [31] and tripterygium glycosides [32], can effectively treat diverse autoimmune diseases in animals and humans. CLT, a pentacyclic triterpene derived from Thunder of God Vine, is a potent agent with antitumor, anti-inflammatory, and immunosuppressive effects in animal models and clinical trial [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Celastrol alleviates murine lupus nephritis via inducting CD4+Foxp3+ regulatory T cells

Xiang

Shi

Wang

2022

Folia Histochem Cytobiol.

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Section: Discussionmentioning

confidence: 99%

Celastrol alleviates murine lupus nephritis via inducting CD4+Foxp3+ regulatory T cells

Xiang

Shi

Wang

2022

Folia Histochem Cytobiol.

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Efficacy and safety of Tripterygium glycosides as an add-on treatment in adults with chronic urticaria: a systematic review and meta-analysis

Xiang

2023

Pharmaceutical Biology

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Context Tripterygium glycosides (TG), a traditional Chinese medicine, has been used to treat chronic urticaria (CU) in China, and the evidence of TG for CU needs to be updated thoroughly. Objective To systematically evaluate the efficacy and safety of TG combined with H1-antihistamine (H1-AH) in adults with CU. Methods Eligible randomized controlled trials were searched in eight databases until May 31, 2022, including CNKI, WanFang, VIP, SinoMed, PubMed, Cochrane Library, Embase, and Web of Science. The search terms included urticaria, Tripterygium , Lei Gong Teng, and Leigongteng. Rev Man 5.3 and Stata 12.0 were used for statistical analysis. Results A total of 27 studies with 2788 patients were included. The pooled results showed that TG plus H1-AH was superior to H1-AH alone in cure rate (RR = 1.37, 95% CI = 1.15 to 1.63, p = 0.0003), total efficacy rate (RR = 1.40, 95% CI = 1.30 to 1.50, p < 0.00001), pruritus (MD = −0.32, 95% CI = −0.54 to −0.11, p = 0.003), wheal number (MD = −0.31, 95% CI = −0.55 to −0.07, p = 0.01), wheal size (MD = −0.32, 95% CI = −0.46 to −0.19, p < 0.00001), and the serum level of immunoglobulin E (SMD = −1.39, 95% CI = −2.42 to −0.36, p = 0.008). Moreover, adverse events between two groups were mild, and their incidences were not significantly different. Conclusions The combination of TG and H1-AH is a promising and safe treatment for adults with refractory CU. Further high-quality studies are needed to confirm the evidence.

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Traditional Chinese medicine for sjögren’s syndrome: a national survey of attitudes and perceptions among Chinese patients and rheumatologists

Liu,

Guo,

et al. 2024

BMC Complement Med Ther

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Background This study explored similarities and differences among Chinese patients and rheumatologists in their attitudes towards and perceptions of traditional Chinese medicine (TCM) for Sjögren’s syndrome (SS), including analyzing factors that influenced their decision making. Methods An anonymous questionnaire was used to conduct a multicenter survey among patients with SS at three tertiary care medical centers in Beijing and among rheumatology clinicians at several hospitals across China. Results were analyzed using descriptive statistics. Results There were 942 valid questionnaires from patients from 31 provinces and cities in China, with a male-to-female ratio of approximately 1:14, a mean age of 48.81 years, and a median disease duration of 7 (4, 10) years. There were 320 valid questionnaires from rheumatologists, covering 30 provinces and cities in China, with a male-to-female ratio of approximately 0.87:1, a mean age of 48 years, and a median work duration of 10.5 (6, 15) years. The rheumatologists treated a median of 15 (11, 50) SS cases per month, and the median proportion of SS to all rheumatic diseases was 6.66% (6–10%). Many patients believed TCM could cure the root of the disease, and the most expected TCM therapies were TCM patent prescriptions and medicinal teas. Conversely, rheumatologists placed high value on the efficacy of TCM, and most commonly prescribed Chinese herbal decoctions. Most doctor-patient groups were positive about TCM treatment, citing the low side effects as the major advantage. Regression analysis showed that for patients over 40 years old with a course of disease > 4 years, the probability of using TCM has increased by 1–6 times; the probability of recommending TCM in clinical work of doctors who have worked for more than 15 years, TCM and integrated traditional Chinese and western medicine has increased 1–2 times. Conclusions TCM has become widely accepted and earned attention from doctor-patient groups, especially among older patients and experienced rheumatologists. However, negative prejudices and absence of accurate information about TCM treatments and SS itself require improvement. The contradiction between TCM dosage form and efficacy is a major problem, and patient demand for convenient and efficient TCM patent preparations suggests future work should focus on developing TCM patent preparations with clear compositions and mechanisms.

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Efficacy and safety of Tripterygium glycosides in Sjögren’s syndrome treatment: evidence from 12 randomized controlled trials

Abstract: Background: Tripterygium glycosides (TGs) has been widely used in the treatment of Sjögren's syndrome (SS).

Cited by 3 publications

References 23 publications

Celastrol alleviates murine lupus nephritis via inducting CD4+Foxp3+ regulatory T cells

Celastrol alleviates murine lupus nephritis via inducting CD4+Foxp3+ regulatory T cells

Efficacy and safety of Tripterygium glycosides as an add-on treatment in adults with chronic urticaria: a systematic review and meta-analysis

Traditional Chinese medicine for sjögren’s syndrome: a national survey of attitudes and perceptions among Chinese patients and rheumatologists

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