Efficacy and safety of Tuina for treatment of pediatric recurrent respiratory tract infections

Tian, Yange; Wang, Lie; Wang, Zhongtian; Ding, Lizhong; Wei, Li‐Na; Guo, Lei; Sun, Xiaozhou; Wang, Lei; Yang, Fushuang; Sun, Liping

doi:10.1097/md.0000000000027939

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…Найчастіше в наукових публікаціях повідомляється, що суттєві й різноспрямованіу бік зменшення або збільшення -відхилення фізичного розвитку дітей зумовлюють їхню вищу схильність до РРІ [1,4,14,23]. З іншого боку, відзначається наявність вираженого негативного впливу частих епізодів ГРІ на їхні антропометричні показники [5,22,27]. Отже, порушення фізичного розвитку й РРІ в дітей знаходяться у двоспрямованому причиннонаслідкову зв'язку.…”

Section: результати дослідження та їх обговоренняunclassified

Variability of basic anthropometric indicators in children aged 12-59 months with different frequency of acute respiratory infections in their medical history

Marushko,

Voloshin,

Savchenko

et al. 2024

MPU

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Aim - to determine the state of interdependence between the frequency of acute respiratory infections (ARI) episodes in children aged 12-59 months and basic indicators of their physical development. Materials and methods. A total of 136 children (68 boys and 68 girls) aged 12-59 months, undergoing inpatient treatment on ARI, were involved in the clinical study. The number of ARI episodes during the previous year of their life was taken into account. Additionally, two integral indices of ARI recurrence, specifically the infection index (InI) and resistance index (RI), were calculated. The basic indicators of physical development were assessed in the children, including: 1) body weight (BW); 2) body length (BL); 3) body surface area (BSA); 4) body mass index; 5) chest circumference; 6) integral index of dolichostenomelia. For the comparative analysis of the results obtained, the current standards of physical development indicators for children from the World Health Organization were used. The statistical processing of the digital data was performed with IBM SPSS Statistics 28 licensed software. Results. In the examined children, InI was inversely and moderately correlated with BW, BL, BSA, and chest circumference. According to this correlation, higher InI was combined with lower physical development indicators. On the contrary, a direct and weakly expressed interdependence with BW, BL, and BSA was found for RI. It was confirmed by registration of bigger RI against the background of higher anthropometric parameters. A cross-tabulation demonstrated a moderate relationship between the frequency of ARI episodes, on the one hand, and the considered centile intervals for BL (φc=0.362; p=0.037) as well as the Z-intervals for the integral anthropometric parameter - BL/child’s age (φc=0.348; p=0.006), on the other hand. Conclusions. A linear regression analysis carried out in the children demonstrates the dependence of the frequency of ARI episodes only on their age. At that, none of the studied anthropometric indicators is represented in the resulting prognostic model. The absence of these indicators in the model obtained may be explained, firstly, by the small number of the examined patients, whose BW and BL belonged to 2 extreme centile intervals: 3-5% and 95-97%. Secondly, it is likely that the further study of the relationship between the frequency of ARI episodes and physical development indicators would be more advisable to undertake in children groups with narrower age ranges. The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the local ethics committees of the institutions mentioned in the paper. An informed parental consent was obtained for the study in children. No conflict of interests was declared by the authors.

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Section: результати дослідження та їх обговоренняunclassified

Variability of basic anthropometric indicators in children aged 12-59 months with different frequency of acute respiratory infections in their medical history

Marushko,

Voloshin,

Savchenko

et al. 2024

MPU

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“…It is a noninvasive treatment, well-accepted by children, and effective in clinical applications for conditions such as cough, recurrent respiratory infections, acute diarrhea, congenital myxomatosis, and anorexia. [10][11][12][13][14][15] From the perspective of traditional Chinese medicine (TCM), the pathogenesis of TD in children is hyperactivity of Yang and disharmony of Yin and Yang. Massage aims to restore yin and yang balance.…”

Section: Introductionmentioning

confidence: 99%

Pediatric massage therapy for treatment of tic disorders in children: A systematic review and meta-analysis of randomized controlled trials

Wu,

Yang,

Wang

et al. 2024

Medicine

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Background: Tic disorder is a common neurodevelopmental disorder in childhood, characterized primarily by motor or vocal tics. However, there is no systematic evaluation of pediatric massage therapy for children with Tic disorder. This study aims to evaluate the effectiveness and safety of massage therapy for children with tic disorder through a comprehensive meta-analysis and systematic review. Methods: We systematically searched relevant randomized controlled trials from various databases such as CBM, CNKI, VIP, Wanfang database, PubMed, Embase, Web of Science, Cochrane Library, and SINOMED, published up to October 2023. To collect randomized controlled trials on pediatric massage therapy or in combination with other therapies for the treatment of tic disorders in children. The risk of bias in the included articles was assessed using the Cochrane guideline. Meta-analyses were performed using Review Manager 5.4, and publication bias was evaluated by using Begg test and Egger test in Stata SE software. Results: This meta-analysis included 19 randomized controlled trials with 1423 patients. Pediatric massage therapy alone or in combination with conventional medication demonstrated a significant increase in clinical effectiveness rates [risk ratios = 1.15, 95% confidence interval [CI] (1.10, 1.20), Z = 6.54, P < .001], and reduced Yale Global Tie Severity Scale scores [standardized mean difference = −0.85, 95% CI (−1.50, −0.19), Z = 2.54, P = .01] and traditional Chinese medicine syndrome scores [standardized mean difference = −1.35, 95%CI (−2.08, −0.63), Z = 3.66, P = .0002]. In terms of adverse reactions, there was no statistical difference between the experimental and control groups [risk ratios = 0.26, 95% CI (0.14, 0.49), Z = 4.25, P < .001]. The Begg test and Egger test results indicated no publication bias. Conclusion: Evidence suggests that pediatric massage therapy is effective in improving tic disorders in children.

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“…As an ancient medicine, traditional Chinese medicine (TCM) has accumulated precious experience for clinical treatment and medical research in various fields for a long time [ 7 ]. TCM has played an important role as a complementary alternative therapy in East Asia.…”

Section: Introductionmentioning

confidence: 99%

Reveal the Patterns of Prescriptions for Recurrent Respiratory Tract Infections’ Treatment Based on Multiple Illustrious Senior Traditional Chinese Medicine Practitioners

Wang

Zhou

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. Recurrent respiratory tract infections (RRTIs) are one of the most common diseases in children and adolescents. The causes of RRTIs are various. In addition to the factors related to infection, basic diseases such as respiratory system, immune system, and digestive system are also involved. The cost of patients’ frequent medical treatment and hospitalization has been deemed to be a heavy burden to the society and family. In China, traditional Chinese medicine (TCM) is commonly used to treat RRTIs. TCM treatment has been appraised to be effective, for reducing the number of hospital stays. Illustrious senior TCM practitioners of pediatrics are recognized as a group of outstanding physicians with significantly better patient outcomes. However, different illustrious senior TCM practitioners can lead to differences in treatment strategies due to factors such as region, prescription theory, and individual differences of patients. This makes it difficult for the experience of illustrious senior TCM practitioners to be popularized. However, there have been no prescription mining studies for the treatment of RRTIs based on different and multiple illustrious senior TCM practitioners. We explored the core prescriptions and drug mechanisms through data mining based on the prescriptions of illustrious senior TCM practitioners treating RRTIs from different clinical settings. This is important to promote the effective treatment of RRTIs with TCM. The objective of this study is to reveal the strategies (core prescriptions) from the prescriptions of multiple illustrious senior TCM practitioners for the treatment of RRTIs. We hope that this core prescription can help all TCM pediatricians to improve RRTIs children’s outcome. Meanwhile, it could provide a new way for researchers to study the treatment of RRTIs. Methods. In this study, we prospectively collected 400 children’s prescriptions with RRTIs receiving TCM treatment from four illustrious senior TCM practitioners in different hospitals. We described and analyzed the characteristics of TCM prescriptions. The prescription regularity was analyzed by hierarchical clustering and association rules. Network pharmacology methods has been used to reveal the pathway mechanism of core prescriptions which have been mined and visualized with the help of SymMap, Genecards, KEGG, Metascape databases, and R. The execution of all methods was completed in May 2022. Results. According to RRTIs multiple clinical syndromes, five new prescriptions were obtained based on illustrious senior TCM practitioners. Among them, the prescription composed of Scutellariae radix (Huangqin), Armeniacae semen amarum (Kuxingren), Peucedani radix (Qianhu), and Pheretima (Dilong) is the core strategy for the treatment of RRTIs. Cold herbs and heat herbs in the core prescription are approximately equal. Scutellariae radix (Huangqin) was dominant, and other herbs exert synergistic effects. The core prescription covered 76 pathways and 226 herb-disease genes. It promotes the differentiation of Th1, Th2, and Th17 cells and the secretion of inflammatory factors through toll-like receptor signaling pathway in the immune system, T cell receptor signaling pathway, and PPAR signaling pathway in the endocrine system, thereby exerting immune regulation and anti-inflammation. Conclusion. In this study, we revealed the prescription regularity of TCM in the treatment of RRTIs and analyzed the mechanism of core prescriptions, which provided new ideas for the treatment of RRTIs.

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Efficacy and safety of Tuina for treatment of pediatric recurrent respiratory tract infections

Cited by 4 publications

References 12 publications

Variability of basic anthropometric indicators in children aged 12-59 months with different frequency of acute respiratory infections in their medical history

Variability of basic anthropometric indicators in children aged 12-59 months with different frequency of acute respiratory infections in their medical history

Pediatric massage therapy for treatment of tic disorders in children: A systematic review and meta-analysis of randomized controlled trials

Reveal the Patterns of Prescriptions for Recurrent Respiratory Tract Infections’ Treatment Based on Multiple Illustrious Senior Traditional Chinese Medicine Practitioners

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