Efficacy and safety of two Ayurvedic dosage forms for allergic rhinitis: Study protocol for an open-label randomized controlled trial

Dahanayake, Jeevani Maheshika; Perera, Pathirage Kamal; Galappaththy, Priyadarshani; Samaranayake, Dulani

doi:10.1186/s13063-019-4004-1

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…It is currently acknowledged that the severe symptoms of AR greatly influence the QOL of patients and are related to various conditions including cognitive impairment, headache, fatigue, and sleep disturbances. 39 Furthermore, the presence of nasal and ocular symptoms among AR individuals contributes to poor QOL, lowered work productivity, and elevated resource utilization. 40 Given the significant changes in QOL among patients with AR, we further assessed the potential relationship between BCL6 of AR are attributed to IgE-regulated responses to various inhaled allergens and Th2 cell-triggered mucosal inflammation.…”

Section: Bcl6 Low Expression Affected Qol Of Patients With Armentioning

confidence: 99%

Correlation between B-cell lymphoma 6 with the balance of T helper-1/2 and severity of allergic rhinitis

Wu¹,

Chen

2023

Allergol Immunopathol

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Objective: Allergic rhinitis (AR) is a prevailing immune disorder affecting the nasal mucosa. B-cell lymphoma 6 (BCL6) imposes essential roles in immunity. This study probed into the serum expression of BCL6 and its effect on AR diagnosis and patients’ quality of life (QOL). Methods: A total of 113 patients with AR including 38 cases with mild AR (MAR) and 75 cases with moderate-severe AR (MSAR) were enrolled, with 101 healthy people enrolled as control. Serum expression of BCL6 was detected by RT-qPCR and the diagnostic efficacy of BCL6 for AR was analyzed using the receiver operating characteristic curve. The proportion of T helper-1/2 (Th1/Th2) cells in CD4+ T cells in peripheral blood mononuclear cells was detected using flow cytometry. The correlation between BCL6 and Th1/Th2 cells and the effects of BCL6 expression on patients’ QOL were assessed by Pearson analysis and Mini-RQLQ questionnaire. Results: BCL6 was downregulated in patients with AR, serum BCL6 level < 0.8450 had certain auxiliary diagnostic values for AR, and serum BCL6 level < 0.5400 could assist the diagnosis of AR severity. Th1 cell proportion in CD4+ T cells was decreased, whereas Th2 cell proportion was increased with AR severity. BCL6 was positively-linked with Th1 cells but inversely-correlated with Th2 cells in patients with AR. Patients with AR with low BCL6 expression had a poorer QOL compared with high BCL6 expression. The domains most affected by BCL6 expression were practical problems, nasal symptoms, and lacrimation. Conclusion: Serum BCL6 is downregulated and low BCL6 expression greatly deteriorates QOL in patients with AR.

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Section: Bcl6 Low Expression Affected Qol Of Patients With Armentioning

confidence: 99%

Correlation between B-cell lymphoma 6 with the balance of T helper-1/2 and severity of allergic rhinitis

Wu¹,

Chen

2023

Allergol Immunopathol

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“…Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract characterized by nasal congestion, watery nasal discharge, itchy nose, and sneezing. It is caused by IgE-mediated reactions against inhaled allergens [ 1 , 2 ] . Epidemiological studies have reported that nearly 10–40% of the global population is affected by AR, with increasing incidence [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Association of serum CD14 level and functional polymorphism C-159T in the promoter region of CD14 gene with allergic rhinitis

Kamel,

Selim,

Tantawy

et al. 2023

Clin Exp Med

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Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract affecting a significant number of the world’s population. It occurs as an IgE-mediated immune response of the nasal mucosa to inhaled allergens. The human Cluster of Differentiation 14 (CD14) is a glycosyl-phosphatidylinositol-anchored molecule expressed on the surface of monocytes and macrophages and functions as a receptor to lipopolysaccharides and inhaled endotoxins that may stimulate interleukins production by antigen-presenting cells. Consequently, CD14 plays a substantial role in allergic diseases and may become one of their etiological causes. Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract affecting a significant number of the world’s population. It occurs as an IgE-mediated immune response of the nasal mucosa to inhaled allergens. The human Cluster of Differentiation 14 (CD14) is a glycosyl-phosphatidylinositol-anchored molecule expressed on the surface of monocytes and macrophages and functions as a receptor to lipopolysaccharides and inhaled endotoxins that may stimulate interleukins production by antigen-presenting cells. Consequently, CD14 plays a substantial role in allergic diseases and may become one of their etiological causes. This study aimed to determine the association between C-159T polymorphism in the CD14 gene promoter region and serum CD14 levels and the risk of Allergic rhinitis Egyptian patients and to test the validity of serum CD14 level measurement in predicting AR. This case–control study included 45 patients with AR referred to Allergy and Immunology Unit, Zagazig University Hospital, Zagazig, Egypt, and 45 healthy subjects as controls. Serum CD14 levels were measured by ELISA. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect C-159T gene polymorphism in the CD14 promoter region. This case–control study included 45 patients with AR referred to Allergy and Immunology Unit, Zagazig University Hospital, Zagazig, Egypt, and 45 healthy subjects as controls. Serum CD14 levels were measured by ELISA. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect C-159T gene polymorphism in the CD14 promoter region. There was a significant association between CD14 serum levels and AR incidence (P < 0.001), with patients having higher serum CD14 levels than controls. In addition, a significant association (P < 0.001) was detected between serum CD14 levels and the severity of AR, as well as elevated serum CD14 levels in severe and the most severe cases. On the molecular level, there was a statistically significant relationship between patients and the control group regarding the CD14 genotype (P < 0.001), where CT and TT genotypes and T allele were primarily associated with the cases group, indicating that the risk of AR was significantly associated with the inheritance of the TT genotype. Additionally, a statistically significant association was found between the severity of AR and CD14 genotype (P < 0.001), where TT genotypes were mainly associated with severe and the most severe cases. In the studied groups, there was a statistically significant difference (P < 0.05) between the CD14 genotype and serum CD14 levels, with TT genotypes being associated with higher CD14 levels. The results obtained in this study revealed that serum CD14 level is a potential biomarker for the diagnosis of AR and, at the genetic level, a potential predictor of disease.

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“…Presently, in addition to the standard classical Ayurveda and indigenous medical dosage forms, novel dosage forms such as tablets, capsules, syrups, etc., are emerging to increase palatability (Zaigham et al, 2019). Ready-to-use freeze-dried powder (reconstituted powder) is also a recently explored novel dosage form tested for its safety and efficacy (Dahanayake et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Evaluating attitudes towards Ayurveda and Sri Lankan Indigenous Medicine (Deshiya Chikitsa) among working adults

Fyzer,

Weerakoon

2023

UCR

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Sri Lanka has a pluralistic healthcare system. Allopathic medicine (synonym for the conventional, modern, or western medicine) currently dominates the Sri Lankan healthcare system. Ayurveda and indigenous Sri Lankan medicines (Deshiya Chikitsa) have been employed as complementary medicines. This descriptive crosssectional article evaluates the level of awareness, utilization, and preference for Ayurveda and Sri Lankan indigenous medicine among an adult working population in the Colombo district. The sample consisted of 154 individuals aged 20 to 59 years old selected from two Colombo workplaces. The participants completed a self-administered questionnaire that asked about their awareness, utilization, and preference for Ayurveda and Sri Lankan indigenous medicine. The outcomes were assessed using the criterion of demographic analysis. According to the findings of this article, the majority of participants (98.05%) are aware that Sri Lanka possesses alternative medical systems such as Ayurveda and Sri Lankan indigenous medicine, and that the source of such awareness is their parents. However, knowledge about the medicine’s use and effectiveness is limited. Despite this, 88.07% of participants have received Ayurvedic treatment or indigenous medicine from a qualified practitioner at least once in their lives, 60.93% would prefer to utilize them, and 87.42% would suggest Ayurveda and Sri Lankan indigenous medicines. This article also identifies and provides reasons for the lack of preference for Ayurveda and Sri Lankan indigenous medicine over conventional medicine, along with suggestions to enhance preference for Ayurveda and Sri Lankan indigenous medicine over conventional medicine.

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Efficacy and safety of two Ayurvedic dosage forms for allergic rhinitis: Study protocol for an open-label randomized controlled trial

Cited by 6 publications

References 11 publications

Correlation between B-cell lymphoma 6 with the balance of T helper-1/2 and severity of allergic rhinitis

Correlation between B-cell lymphoma 6 with the balance of T helper-1/2 and severity of allergic rhinitis

Association of serum CD14 level and functional polymorphism C-159T in the promoter region of CD14 gene with allergic rhinitis

Evaluating attitudes towards Ayurveda and Sri Lankan Indigenous Medicine (Deshiya Chikitsa) among working adults

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