Efficacy and safety of two different antifungal pastes in infants with diaper dermatitis: a randomized, controlled study

Abstract

Clotrimazole was superior to nystatin with respect to reduction in symptom score and GA. Microbiological cure rate was 100% for both agents. Both treatments were safe and well-tolerated.

Zinc Oxide 30% and Tocopherol Compared to 10% Zinc Oxide Ointment in the Treatment of Infant's Diaper Dermatitis: A Triple Blinded Controlled Randomized Trial

“…Ointments, which may contain zinc oxide, are recommended as a base-line therapy [9]. Subsequent studies have demonstrated the effectiveness of using diapers with a continuous release of a combination of zinc oxide and petrolatum [10,11]. In the literature, the properties of tocopherol have been analyzed many times in the treatment of skin diseases in the newborn, and in the treatment of surgical wounds with pre and post-surgery administration either as regards the management of lesions or the maceration of the skin due to the rubbing on the surface of the diaper or to stagnation of material such as feaces and urine in the most prone area to the onset of dermatitis [12].…”

Answers to Dermatophile

“…Systemic antibiotic therapy is a well-known trigger, especially in infants. Antifungal agents, such as topical nystatin or miconazole can be used, associated with gentle cleansing of the diaper area 4. If necessary, oral nystatin may be administered.…”

Windeldermatitis

“…Als antimykotische Lokaltherapie können beispielsweise Clotrimazol-, Miconazol-, Ciclopirox-oder Nystatin-haltige Externa eingesetzt werden [12,21]. Dieses sollte allerdings nicht grundsätzlich erfolgen, sondern nur bei klinischem Anhalt bzw.…”