Efficacy and safety of uninterrupted rivaroxaban taken preoperatively for radiofrequency catheter ablation of atrial fibrillation compared to uninterrupted warfarin

Abstract

Uninterrupted rivaroxaban taken preoperatively for AF ablation is clinically effective and safe. Its ACE profile is similar to warfarin. ACT is sufficient for monitoring anticoagulation.

Safety and efficacy of DOACs vs acenocoumarol in patients undergoing catheter ablation of atrial fibrillation

“…In concordance with our results, Lakkireddy et al demonstrated that uninterrupted rivaroxaban is as safe and efficacious in preventing bleeding and thromboembolic events in patients undergoing AF ablation as is uninterrupted warfarin therapy . Tao et al also confirmed our results in their prospective study clarifying the safety and efficacy of using uninterrupted morning rivaroxaban for anticoagulation during AF ablation, especially with regard to asymptomatic cerebral embolism and anticoagulation parameters . In addition, Kuwahara et al reported that apixaban 5 mg or 2.5 mg b.i.d.…”

“…11 Tao et al also confirmed our results in their prospective study clarifying the safety and efficacy of using uninterrupted morning rivaroxaban for anticoagulation during AF ablation, especially with regard to asymptomatic cerebral embolism and anticoagulation parameters. 22 In addition, Kuwahara et al reported that apixaban 5 mg or 2.5 mg b.i.d. has similar safety and effectiveness to warfarin for the prevention of cerebral thromboembolism during the periprocedural period of AF ablation.…”

An updated meta-analysis of novel oral anticoagulants versus vitamin K antagonists for uninterrupted anticoagulation in atrial fibrillation catheter ablation

“…For all other studies, major bleeding was defined as that severe enough to require blood transfusion, surgery, or pericardial drainage. 12,17,18,[20][21][22] In the COMPARE study 7 of continuous vs interrupted warfarin, major bleeding was defined more broadly as cardiac tampo-nade, hematoma requiring intervention, massive hemoptysis, hemothorax, retroperitoneal bleeding, need for transfusion, or bleeding causing symptoms. As reported in Table 1, follow-up for bleeding end points ranged from inhospital to as much as 90 days.…”

“…More recently, numerous studies were published, including additional randomized data that may strengthen the power of pooled outcomes. [10][11][12][13] Therefore, we aimed to perform an updated systematic review and meta-analysis to investigate the efficacy and safety of NOACs vs VKAs for uninterrupted OAC in patients with AF undergoing catheter ablation.…”

Safety and efficacy of nonvitamin K antagonist oral anticoagulants during catheter ablation of atrial fibrillation: A systematic review and meta‐analysis

“…A total of 2694 records were identified, of which 29 studies met the predefined criteria and hence were included in the analysis. The detailed search flowchart was illustrated in Figure .…”