Efficacy and safety of urinary catheters with silver alloy coating in patients with spinal cord injury: a multicentric pragmatic randomized controlled trial. The ESCALE trial

Esteban-Fuertes, M.; Jauregui-Abrisqueta, M.L.; Alemán-Sánchez, Carolina; Bea-Muñoz, Manuel; Bonfill, Xavier; Rigau, David; Martinez‐Zapata, Maria José; Cánovas, Esther; Zazo, Nuria; Gich, Ignasi; Martínez-Zapata, Ma José; Bea, Manuel Martínez; Garran, Mónica; Borau, A.; Herrero, María Paz; Morcillo, Montse; Alemán, Carolina; Barbara, E.; Jáuregui, María Luisa; Cuadrado, Montserrat; Sánchez, Nora Cívicos; Mendieta, Ines Lodeiro; Salvador, Sebastián; Montoto, Antonio; Ferreiro, ME; Espinosa, Juan R.; Moraleda, Susana; Barrera-Chacon, J.M; Mendez, B. Díaz; Zarco, María José; García, Inmaculada García; Esteban, M.; Florencio, Manuel; Hidalgo, Begoña; Miguel, Juan Ignacio de; Lanzillotti, Crocifissa Maria; Navarro, Jorge; Andrade, Maria João; Soares, Diogo; Akkoç, Yeşim; Şenocak, Özlem; Vásquez, Nelson Núñez; Orrego, Viviana; Courbis, Marcia; Seguel, Maritza

doi:10.1016/j.spinee.2017.05.025

Cited by 29 publications

(21 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The ESCALE trial, a trial of silver‐alloy catheters in spinal cord injury patients, reported more AEs possibly related to catheterization with the experimental catheters compared to standard catheters, including itching which was not reported in the control group . Other AEs captured by the ESCALE trial included haematuria, rash, blockage, and suprapubic pain .…”

Section: Discussionmentioning

confidence: 99%

A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long‐term use

Belfield

Betts

Parkinson

et al. 2018

Neurourology and Urodynamics

View full text Add to dashboard Cite

Aims:We have developed a novel antimicrobial urinary catheter (AUC) impregnated with rifampicin, triclosan, and sparfloxacin and demonstrated that it has long-term (∼84 days) protection against bacterial colonization in vitro. This study aimed to assess the safety and patient acceptability of this device in long-term catheter users. Methods: Adults who use long term (>28 days) indwelling urinary catheters with capacity to consent were invited to receive the AUC at their next catheter change. The primary outcome measure was adverse events (AE) attributable to antimicrobial impregnation of the catheter. Secondary outcome measures included severity of related AEs, patient acceptability, early removal of the trial catheter, and degree of microbial colonization of trial catheters. Except for the last, outcomes were assessed by telephone interviews. Original and trial catheters were collected, and the lumens and balloons were separated and analyzed for microbiological colonization. Results: Thirty participants were recruited. Eighty four AEs were reported, and only one was rated as "probably" related to antimicrobial impregnation. The AE was mild and resolved within 48 h. A total of 82.14% of participants rated the catheter as no different or better than their usual catheter. Two participants chose to remove the AUC early due to it feeling shorter. There were significantly fewer bacterial isolates attached to the balloons of trial catheters compared to the matched original catheters. Conclusions: The AUC has an advantageous safety profile and was acceptable to the majority of participants. Information gained from this trial will support a larger randomized controlled study of efficacy. K E Y W O R D Santi-infective agents, catheter-related urinary tract infections, clinical trial, safety, urinary catheters

show abstract

Section: Discussionmentioning

confidence: 99%

A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long‐term use

Belfield

Betts

Parkinson

et al. 2018

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…Еволю-ційно мікроорганізми та людина розвинули здатність співіснувати, умовно-патогенна мікрофлора виробила властивості персистенції [12]. Тому EAU (2017) пропо-нує не лікувати безсимптомну бактеріурію невагітним жінкам, людям, які страждають від діабету, пацієнтам будинків престарілих, тим, хто має ураження спинного мозку, та при наявних катетерах сечового міхура [13][14][15][16][17].…”

Section: Cover Storyunclassified

“…Evolutionary, microorganisms and humans have developed the ability to co-exist; the conditionally pathogenic microflora has developed the persistence features [12]. Therefore, the EAU 2017 proposes not to treat asymptomatic bacteriuria in non-pregnant women, people with diabetes, nursing home patients, those who have lumbar spinal cord injury and bladder catheters [13][14][15][16][17].…”

Section: Cover Storymentioning

confidence: 99%

Антибіотикорезистентність І Вакцинація При Інфекції Сечового Тракту

Ivanov

2021

KIDNEYS

View full text Add to dashboard Cite

Однією з причин формування антибіотикорезистентності в лікуванні інфекцій сечового тракту є відсутність у рекомендаціях застосування уроантисептиків європейського виробництва, зокрема макмірору та фурамагу. Проблему терапії резистентних, рецидивуючих інфекцій сечового тракту і безсимптомної бактеріурії можна вирішити за допомогою полівакцин, насамперед Уріваку, як самостійної опції, так і у поєднанні з профілактичним лікуванням уроантисептиком і/або фітопрепаратом.

show abstract

“…Hopes have been put to improvement of catheter materials and coating, but studies of catheters for intermittent as well as indwelling use have produced varying results [14,15].…”

Section: Some Authors Have Recognized the Problem Of Recurringmentioning

confidence: 99%

The Stockholm Spinal Cord Uro Study: 2. Urinary tract infections in a regional prevalence group: frequency, symptoms and treatment strategies

Farrelly

Lindbo

Wijkström

et al. 2020

Scandinavian Journal of Urology

View full text Add to dashboard Cite

Objective: To examine symptomatic urinary tract infections (UTI) in a regional prevalence group of patients with traumatic spinal cord injury (SCI), to assess risk factors for recurring infections and to identify a high-risk sub-population for frequently recurring and severe febrile UTIs. Materials and Methods: Four hundred and twelve patients who attended a yearly checkup at the Spinalis SCI clinic were included. A regional programme for neurogenic bladder dysfunction was applied, including S-creatinine and S-cystatin-C, urine culture, residual urine, ultrasound of kidneys, urodynamic studies and a questionnaire regarding complications during the preceding year. Descriptive statistics and regression analysis were used to estimate risk factors. Results: Nearly half of all patients reported 1 UTI during the preceding year with a mean number of 3.6. Persons who use normal voiding had the lowest frequency, while those with catheter-assisted voiding reported the highest numbers. A subgroup of patients had more frequent and severe UTIs. They were characterized by a cervical or thoracic neurological level lesion and a more severe injury and the presence of SCI-related complications such as spasticity, neuropathic pain and autonomic dysreflexia. The most common signs and symptoms of UTI were smelly and cloudy urine, feelings of malaise and increased spasticity. Conclusions: Risk profiles for recurring and severe UTIs were catheter-assisted voiding, cervical or thoracic levels and more complete neurological lesions and the coexistence of other SCI-related complications. There is a need for an increased understanding of the special symptoms of UTI in this patient group and a strategy to avoid unspecific antibiotic treatment.

show abstract

Efficacy and safety of urinary catheters with silver alloy coating in patients with spinal cord injury: a multicentric pragmatic randomized controlled trial. The ESCALE trial

Cited by 29 publications

References 20 publications

A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long‐term use

A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long‐term use

Антибіотикорезистентність І Вакцинація При Інфекції Сечового Тракту

The Stockholm Spinal Cord Uro Study: 2. Urinary tract infections in a regional prevalence group: frequency, symptoms and treatment strategies

Contact Info

Product

Resources

About