Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review

Zhou, Ming; Han, Shiliang; Zhang, Wenpeng; Wu, Dan

doi:10.1007/s00774-022-01342-6

Cited by 13 publications

(6 citation statements)

References 36 publications

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“…), and that vitamin K 2 dosage may be associated with increased in OB activity and inhibition of OC-induced bone resorption [ 103 ] and be involved in the carboxylation of OCN [ 42 ]. An experimental study of Chinese older adults by Zhang et al showed that vitamin K 2 supplementation at 90 μg/d can effectively alleviate bone loss in postmenopausal women [ 104 ] and confirmed its efficacy and safety in a Meta-analysis [ 105 ].…”

Section: Macronutrients and Micronutrientsmentioning

confidence: 99%

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Zeng,

Qian,

Yang

et al. 2024

Heliyon

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Section: Macronutrients and Micronutrientsmentioning

confidence: 99%

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Zeng,

Qian,

Yang

et al. 2024

Heliyon

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Section: Vitamin Kmentioning

confidence: 99%

“…75 However, there are more recent meta-analyses with positive results, concluding that vitamin K2 supplementation helps maintain and improve BMD in postmenopausal women, and reduces the incidence of fractures. 11,76 Vitamin K2, or menaquinone, can be divided into short-chain and long-chain menaquinones. Menaquinones are primarily produced by bacteria, so the primary dietary sources of these compounds are fermented foods like cheeses, although they can also be found in fish, eggs, or liver.…”

Section: Vitamin Kmentioning

confidence: 99%

Nutrition-Based Support for Osteoporosis in Postmenopausal Women: A Review of Recent Evidence

Alabadi,

Civera,

Moreno-Errasquin

et al. 2024

IJWH

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Postmenopausal osteoporosis stands as the predominant bone disorder in the developed world, posing a significant public health challenge. Nutritional factors play a crucial role in bone health and may contribute to its prevention or treatment. Calcium and vitamin D, extensively studied with robust scientific evidence, are integral components of the non-pharmacological treatment for this disorder. Nevertheless, other less-explored nutritional elements appear to influence bone metabolism. This review provides a comprehensive summary of the latest evidence concerning the relationship between various nutrients, such as phosphorus, magnesium, vitamins, phytate, and phytoestrogens; specific foods like dairy or soy, and dietary patterns such as the Mediterranean diet with bone health and osteoporosis.

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“…VK has been shown to be a cost-effective strategy for preventing fractures in older women ( 70 ). A recent meta-analysis of 16 randomized controlled trials with 6,425 subjects involved demonstrated that VK 2 supplementation significantly improved BMD and reduced the risk of fractures ( 71 ), as well as undercarboxylated OCN levels ( 72 ) in post-menopausal women. Similarly, other meta-analyses have demonstrated positive impact of vitamin K on BMD and fracture risk ( 73 ).…”

Section: Vitamin Kmentioning

confidence: 99%

Role of vitamins beyond vitamin D₃ in bone health and osteoporosis (Review)

Skalny,

Aschner,

Tsatsakis

et al. 2023

Int J Mol Med

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The objective of the present review was to summarize the molecular mechanisms associated with the effects of the vitamins A, C, E and K, and group B vitamins on bone and their potential roles in the development of osteoporosis. Epidemiological findings have demonstrated an association between vitamin deficiency and a higher risk of developing osteoporosis; vitamins are positively related to bone health upon their intake at the physiological range. Excessive vitamin intake can also adversely affect bone formation, as clearly demonstrated for vitamin A. Vitamins E (tocopherols and tocotrienols), K 2 (menaquinones 4 and 7) and C have also been shown to promote osteoblast development through bone morphogenetic protein (BMP)/Smad and Wnt/β-catenin signaling, as well as the TGFβ/Smad pathway (α-tocopherol). Vitamin A metabolite (all-trans retinoic acid) exerts both inhibitory and stimulatory effects on BMP- and Wnt/β-catenin-mediated osteogenesis at the nanomolar and micromolar range, respectively. Certain vitamins significantly reduce receptor activator of nuclear factor kappa-B ligand (RANKL) production and RANKL/RANK signaling, while increasing the level of osteoprotegerin (OPG), thus reducing the RANKL/OPG ratio and exerting anti-osteoclastogenic effects. Ascorbic acid can both promote and inhibit RANKL signaling, being essential for osteoclastogenesis. Vitamin K 2 has also been shown to prevent vascular calcification by activating matrix Gla protein through its carboxylation. Therefore, the maintenance of a physiological intake of vitamins should be considered as a nutritional strategy for the prevention of osteoporosis.

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Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review

Cited by 13 publications

References 36 publications

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Nutrition-Based Support for Osteoporosis in Postmenopausal Women: A Review of Recent Evidence

Role of vitamins beyond vitamin D₃ in bone health and osteoporosis (Review)

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Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review

Cited by 13 publications

References 36 publications

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Nutrition-Based Support for Osteoporosis in Postmenopausal Women: A Review of Recent Evidence

Role of vitamins beyond vitamin D3 in bone health and osteoporosis (Review)

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Role of vitamins beyond vitamin D₃ in bone health and osteoporosis (Review)